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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 344 - 351 (8page)
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초록· 키워드
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ObjectiveThe main aim of this study was to evaluate cancer antigen 125 (CA125)/carcinoembryonic antigen (CEA) ratio (CCR),as a reliable marker to differentiate ovarian mucinous carcinoma from other epithelial ovarian carcinomas (EOCs),namely serous, clear cell, and endometrioid carcinomas. MethodsFemale patients suffering from different kinds of EOCs whom were subjected to elective surgery at the GangnamSeverance Hospital between January 2008 and December 2016, were included in this study. The serum levels of CA125and CEA were assayed using commercially available kits per the manufacturer's instructions. ResultsThe CCR in mucinous carcinoma (mean 32.1) was significantly lower than that of clear cell (mean 235.0) andendometrioid carcinoma (mean 427.0) in stage I (all P<0.05). In stage II–IV, CCR in mucinous carcinoma (mean 37.6)was significantly lower than that of serous carcinoma (mean 148.0) (P<0.01). The sensitivity and specificity of CCR indetecting mucinous carcinoma from other types of EOC was 75.0% and 77.5%, respectively in stage I and 100.0% and84.4%, respectively in stage II–IV (both cut-off value <90.7). ConclusionThe present results suggest that pretreatment CCR might provide higher specificity and clinically relevant informationas a criterion for the differentiation between ovarian mucinous carcinoma and other types of EOC.
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참고문헌 (30)
참고문헌 신청
Prat J / 2012 / Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features / Virchows Arch 460:237~249
Sturgeon CM / 2008 / National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers / Clin Chem 54:e11~e79
Badgwell D / 2007 / Early detection of ovarian cancer / Dis Markers 23:397~410
Moore RG / 2012 / Serum HE4 levels are less frequently elevated than CA125 in women with benign gynecologic disorders / Am J Obstet Gynecol 206:351
Rustin GJ / 1996 / Defining response of ovarian carcinoma to initial chemotherapy according to serum CA 125 / J Clin Oncol 14:1545~1551
Sturgeon CM / 2008 / National Academy of Clinical Biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers / Clin Chem 54:e11~e79
Badgwell D / 2007 / Early detection of ovarian cancer / Dis Markers 23:397~410
Moore RG / 2012 / Serum HE4 levels are less frequently elevated than CA125 in women with benign gynecologic disorders / Am J Obstet Gynecol 206:351
Rustin GJ / 1996 / Defining response of ovarian carcinoma to initial chemotherapy according to serum CA 125 / J Clin Oncol 14:1545~1551
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