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학술저널
저자정보
Uni Wong (Division of Gastroenterology and Hepatology University of Maryland School of Medicine) Erik B Person (Veterans Affairs Maryland Health Care System Baltimore MD USA) Donald O Castell (of Gastroenterology and Hepatology Medical University of South Carolina College of Medicine) Erik von Rosenvinge (Division of Gastroenterology and Hepatology University of Maryland School of Medicine) Jean-Pierre Raufman (Division of Gastroenterology and Hepatology University of Maryland School of Medicine) Guofeng Xie (Division of Gastroenterology and Hepatology University of Maryland School of Medicine)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.4
발행연도
2018.1
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570 - 576 (7page)

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Background/Aims Swallows with viscous or solid boluses in different body positions alter esophageal manometry patterns. Limitations of previous studies include lack of standardized viscous substrates and the need for chewing prior to swallowing solid boluses. We hypothesize that high-resolution impedance manometry (HRiM) using standardized viscous and super-viscous swallows in supine and upright positions improves sensitivity for detecting esophageal motility abnormalities when compared with traditional saline swallows. To establish normative values for these novel substrates, we recruited healthy volunteers and performed HRiM. Methods Standardized viscous and super-viscous substrates were prepared using “Thick-It” food thickener and a rotational viscometer. All swallows were administered in 5-mL increments in both supine and upright positions. HRiM metrics and impedance (bolus transit) were calculated. We used a paired two-tailed t test to compare all metrics by position and substrate. Results The 5-g, 7-g, and 10-g substrates measured 5000, 36 200, and 64 700 mPa sec, respectively. In 18 volunteers, we observed that the integrated relaxation pressure was lower when upright than when supine for all substrates (P < 0.01). The 10-g substrate significantly increased integrated relaxation pressure when compared to saline in the supine position (P < 0.01). Substrates and positions also affected distal contractile integral, distal latency, and impedance values. Conclusions We examined HRiM values using novel standardized viscous and super-viscous substrates in healthy subjects for both supine and upright positions. We found that viscosity and position affected HRiM Chicago metrics and have potential to increase the sensitivity of esophageal manometry.

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