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Background/AimsMost recent studies using high-resolution manometry were based on supine liquid swallows. This study was to evaluate the differences in esophageal motility for liquid and solid swallows in the upright and supine positions, and to determine the per-centages of motility abnormalities in different states.MethodsTwenty-four asymptomatic volunteers and 26 patients with gastroesophageal reflux disease underwent high-resolution man-ometry using a 36-channel manometry catheter. The peristalses of 10 water and 10 steamed bread swallows were recorded in both supine and upright positions. Integrated relaxation pressure, contractile front velocity, distal latency (DL) and the distal contractile integral (DCI) were investigated and comparisons between postures and boluses were analyzed. Abnormal peristalsis of patients was assessed applying the corresponding normative values.ResultsIn total, 829 swallows from healthy volunteers and 959 swallows from patients were included. (1) The upright position pro-vided lower integrated relaxation pressure, shorter DL and weaker DCI than the supine position. (2) In the comparison of liq-uid swallows, the mean for contractile front velocity was obviously reduced while DL and DCI were increased in solid swallows. (3) The supine position detected more hypotensive peristalsis than the upright position. The upright position provided more rapid and premature contraction than the supine position but there was no statistically significant difference.ConclusionsSupine solid swallows occur with more hypotensive peristalsis. Analysis should be based on normative values from the corre-sponding posture and bolus.

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