지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.2
- 발행연도
- 2018.1
- 수록면
- 317 - 323 (7page)
이용수
초록· 키워드
오류제보하기
Background/Aims Although bisacodyl is a widely administered laxative, its underlying mechanism of action remains generally unknown. This study focuses on investigating the effects of bisacodyl on the human colon muscle contraction, and elucidating its mechanism of action. Methods Sigmoid colon muscle strips (20 longitudinal and 18 circular muscles) were obtained from 20 subjects who underwent colectomy for colon cancer. Isometric force measurements were calculated in response to electrical field stimulation (EFS, 0.3 milliseconds in trains of 10 Hz for 20 seconds, 150 V). Peak and nadir (tone) during and after EFS, were measured in a controlled state, and after sequential addition of bisacodyl (1 μM), atropine (1 μM), N-nitro-L-arginine (L-NNA, 100 μM), MRS2500 (1 μM), and tetrodotoxin (TTX, 1 μM) to the organ bath. Results Transient phasic contractions were observed during EFS, and after cessation of EFS. In the longitudinal muscles, nadir during EFS, and tone after EFS, significantly increased after addition of bisacodyl, and persisted after sequential addition of atropine, L-NNA, MRS2500, and TTX, indicating a direct action of bisacodyl on the smooth muscle. In the second experiment, pretreatment of TTX abolished EFS-induced phasic contractions. Although no phasic contraction was produced after perfusion of bisacodyl, tone was increased, thereby supporting evidence of a direct mechanism of action of bisacodyl on the colon smooth muscle. Conclusions Bisacodyl increases the tone of longitudinal muscle in the human sigmoid colon through a direct action on the smooth muscle. Further study is warranted to investigate the neural mechanism of action of bisacodyl.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Jeong Eun Shin / 2016 / Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition / Journal of Neurogastroenterology and Motility (JNM) 22(3):383~411
Adams WJ / 1994 / Bisacodyl reduces the volume of polyethylene glycol solution required for bowel preparation / Dis Colon Rectum 37:229~233
Hamid SA / 1998 / Bisacodyl and high-amplitude-propagating colonic contractions in children / J Pediatr Gastroenterol Nutr 27:398~402
Bassotti G / 1999 / Endoluminal instillation of bisacodyl in patients with severe (slow transit type) constipation is useful to test residual colonic propulsive activity / Digestion 60:69~73
Schang JC / 1986 / Changes in colonic myoelectric spiking activity during stimulation by bisacodyl / Can J Physiol Pharmacol 64:39~43
Adams WJ / 1994 / Bisacodyl reduces the volume of polyethylene glycol solution required for bowel preparation / Dis Colon Rectum 37:229~233
Hamid SA / 1998 / Bisacodyl and high-amplitude-propagating colonic contractions in children / J Pediatr Gastroenterol Nutr 27:398~402
Bassotti G / 1999 / Endoluminal instillation of bisacodyl in patients with severe (slow transit type) constipation is useful to test residual colonic propulsive activity / Digestion 60:69~73
Schang JC / 1986 / Changes in colonic myoelectric spiking activity during stimulation by bisacodyl / Can J Physiol Pharmacol 64:39~43
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