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자료유형
학술저널
저자정보
Heung-Kwon Oh (Department of Surgery Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Korea) Tae Sik Sung (Department of Surgery Seoul National University College of Medicine Seoul National University Hospital Seoul Korea) Seung-Bum Ryoo (Department of Surgery Seoul National University College of Medicine Seoul National University Hospital Seoul Korea) Kyu Joo Park (Department of Surgery Seoul National University College of Medicine Seoul National University Hospital Seoul Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.29 No.1
발행연도
2023.1
수록면
113 - 121 (9page)
DOI
10.5056/jnm21236

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Background/AimsRadial stretch evokes an increase or decrease in contractions in the lower gastrointestinal tract via mechanosensory enteric neurons that project into the muscle layers. We aim to elucidate the differences in stretch reflexes according to their location in the human colon.MethodsWe used healthy intestinal smooth muscle tissue excised during elective colon cancer surgery. Conventional intracellular recordings from colonic muscle cells and tension recordings of colonic segments were performed. Radial stretch was evoked through balloon catheter inflation. Changes in the membrane potential and frequency, amplitude, and area under the curve of muscle contractions were recorded before and after the radial stretch at proximal and distal segment sites.ResultsIn intracellular circular muscle recordings, hyperpolarization was noted at the distal site of sigmoid colonic segments after radial stretch, in contrast to depolarization at all other sites. In tension recordings at proximal ascending or sigmoid colonic segment sites, contractile activation was observed with statistically significant increases in the frequency, amplitude, and area under the curve after radial stretch. Distal sites of ascending and sigmoid colonic segments showed increase and decrease in contraction, respectively.ConclusionRadial stretch in the human colon (in vitro) evokes excitatory activity at both proximal and distal sites of the ascending colon and at the proximal site of the sigmoid colon, whereas it elicits inhibitory activity at the distal site of the sigmoid colon.

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