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학술저널
저자정보
Camille Bazin (Service de Gastroentérologie Hôpital Nord Assistance Publique - Hôpitaux de Marseille Marseille Fra) Alban Benezech (Service de Gastroentérologie Hôpital Nord Assistance Publique - Hôpitaux de Marseille Marseille Fra) Marine Alessandrini (EA 3279 - Public Health Chronic Diseases and Quality of Life - Research Unit Aix-Marseille Universi) Jean-Charles Grimaud (Plateforme d’Interface Clinique CRN2M CNRS UMR 7286 Aix-Marseille Université Marseille France) Veronique Vitton (Plateforme d’Interface Clinique CRN2M CNRS UMR 7286 Aix-Marseille Université Marseille France)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.2
발행연도
2018.1
수록면
216 - 225 (10page)

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Background/Aims Esophageal motor disorder (EMD) has been shown to be associated with gastroesophageal reflux disease (GERD). However, the association of EMD with a Barrett’s esophagus (BE) is controversial. Our objective was to evaluate whether the presence of EMD was an independent factor associated with BE. Methods A retrospective case-control study was conducted in GERD patients who all had oeso-gastroduodenal endoscopy and high-resolution esophageal manometry. The clinical data collected was known or potential risk factors for BE: male gender, smoking and alcohol consumption, age, body mass index, presence of hiatal hernia, frequency, and age of GERD. EMD were classified according to the Chicago classification into: ineffective motor syndrome, fragmented peristalsis and absence of peristalsis, lower esophageal sphincter hypotonia. Results Two hundred and one patients (101 in the GERD + BE group and 100 in the GERD without BE) were included. In univariate analysis, male gender, alcohol consumption, presence of hiatal hernia, and EMD appeared to be associated with the presence of BE. In a multivariate analysis, 3 independent factors were identified: the presence of EMD (odds ratio [OR], 3.99; 95% confidence interval [CI], 1.71–9.28; P = 0.001), the presence of hiatal hernia (OR, 5.60; 95% CI, 2.45–12.76; P < 0.001), Helicobacter pylori infection (OR, 0.08; 95% CI, 0.01–0.84; P = 0.035). Conclusions The presence of EMD (particularly ineffective motor syndrome and lower esophageal sphincter hypotonia) is a strong independent associated factor of BE. Searching systematically for an EMD in patients suffering from GERD could be a new strategy to organize the endoscopic follow-up.

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