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논문 기본 정보

자료유형
학술저널
저자정보
Satsuki Takahashi (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Tomoaki Matsumura (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Tatsuya Kaneko (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Mamoru Tokunaga (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Hirotaka Oura (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Tsubasa Ishikawa (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Ariki Nagashima (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Wataru Shiratori (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Naoki Akizue (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Yuki Ohta (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Atsuko Kikuchi (Department of Clinical Engineering Center Chiba University Chiba Japan) Mai Fujie (Department of Clinical Engineering Center Chiba University Hospital Chiba Japan) Keiko Saito (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Kenichiro Okimoto (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Daisuke Maruoka (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Tomoo Nakagawa (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Makoto Arai (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Jun Kato (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan) Naoya Kato (Department of Gastroenterology Graduate School of Medicine Chiba University Chiba Japan)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.27 No.4
발행연도
2021.10
수록면
545 - 554 (10page)
DOI
10.5056/jnm20131

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Background/AimsEsophageal motility disorders (EMDs) contribute to the pathophysiology of gastroesophageal reflux disease. However, the causes of EMDs and their impact on gastroesophageal reflux disease-associated symptoms remain unknown. This study aims to elucidate clinical features associated with various types of EMDs in patients with heartburn symptoms. MethodsOf the 511 patients who underwent high-resolution manometry, 394 who were evaluated for heartburn symptoms were examined. Patients subjected to high-resolution manometry were classified into 4 groups: outflow obstruction group, hypermotility group, hypomotility group, and normal motility group. Symptoms were evaluated using 3 questionnaires. Patient characteristics and symptoms for each EMD type were compared with those of the normal motility group. ResultsOf the 394 patients, 193 (48.9%) were diagnosed with EMDs, including 71 with outflow obstruction, 15 with hypermotility, and 107 with hypomotility. The mean dysphagia score was significantly higher in each of the 3 EMD groups compared with those with normal motility. The mean acid reflux and dyspepsia scores were significantly lower in the outflow obstruction group (P < 0.05). The mean body mass index and median Brinkman index were significantly higher in the hypermotility group (P = 0.001 and P = 0.018, respectively), whereas the mean diarrhea and constipation scores were significantly lower in the hypomotility group (P < 0.05). ConclusionsThe results of our study indicate that different EMDs have distinct characteristics. Cigarette smoking and high body mass index were associated with esophageal hypermotility. Assessment of the dysphagia symptom scores may help identify patients with EMDs.

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