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학술저널
저자정보
Kok-Ann Gwee (Department of Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore) Paul Bergmans (Biometrics Department Janssen Cilag Benelux Tilburg The Netherlands) 김진용 (Regional Medical Affairs Janssen Asia-Pacific Singapore) Bogdana Coudsy (Janssen EMEA Issy-les-Moulineaux France) Angelia Sim (Global Clinical Operations Janssen Selangor Malaysia) Minhu Chen (The First Affiliated Hospital of Sun Yat-Sen University Guangzhou China) Lin Lin (The First Affiliated Hospital of Nanjing Medical University People’s Hospital of Jiangsu Province) Xiao-hua Hou (Union Hospital of Tongji Medical College Huazhong University of Science and Technology) Huahong Wang (Gastrointestinal Department Peking University First Hospital Beijing China) Khean Lee Goh (Department of Medicine University of Malaya Kuala Lumpur Malaysia) John A Pangilinan (St Luke’s Medical Center Institute of Digestive and Liver Diseases Quezon The Philippines) 김나영 (서울대학교) Stanislas Bruley des Varannes (Institut des Maladies de l’Appareil Digestif University Hospital of Nantes Nantes France)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.23 No.2
발행연도
2017.1
수록면
262 - 272 (11page)

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Background/Aims. There is a need for a simple and practical tool adapted for the diagnosis of chronic constipation (CC) in the Asian population. This study compared the Asian Neurogastroenterology and Motility Association (ANMA) CC tool and Rome III criteria for the diagnosis of CC in Asian subjects. Methods. This multicenter, cross-sectional study included subjects presenting at outpatient gastrointestinal clinics across Asia. Subjects with CC alert symptoms completed a combination Diagnosis Questionnaire to obtain a diagnosis based on 4 different diagnostic methods: self-defined, investigator’s judgment, ANMA CC tool, and Rome III criteria. The primary endpoint was the level of agreement/disagreement between the ANMA CC diagnostic tool and Rome III criteria for the diagnosis of CC. Results. The primary analysis comprised of 449 subjects, 414 of whom had a positive diagnosis according to the ANMA CC tool. Rome III positive/ANMA positive and Rome III negative/ANMA negative diagnoses were reported in 76.8% and 7.8% of subjects, respectively, resulting in an overall percentage agreement of 84.6% between the 2 diagnostic methods. The overall percentage disagreement between these 2 diagnostic methods was 15.4%. A higher level of agreement was seen between the ANMA CC tool and self-defined (374 subjects [90.3%]) or investigator’s judgment criteria (388 subjects [93.7%]) compared with the Rome III criteria. Conclusion. This study demonstrates that the ANMA CC tool can be a useful for Asian patients with CC.

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