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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 310 - 314 (5page)
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초록· 키워드
오류제보하기
CYP2D6 is primarily responsible for the metabolism of clomiphene citrate (CC). The purpose of the present study was to investigate the relationship between CYP2D6 genotypes, concentrations of CC and its major metabolites and drug response in infertility patients. We studied 42 patients with ovulatory dysfunction treated with only CC. Patients received a dose of 100 mg/day CC on days 3-7 of the menstrual cycle. CYP2D6 genotyping and measurement of CC and the major metabolite concentrations were performed. Patients were categorized into CC responders or non-responders according to one cycle response for the ovulation. Thirty-two patients were CC responders and 10 patients were nonresponders with 1 cycle treatment. The CC concentrations were highly variable within the same group, but non-responders revealed significantly lower (E)-clomiphene concentration and a trend of decreased concentrations of active metabolites compared to the responders. Nine patients with intermediate metabolizer phenotype were all responders. We confirmed that the CC and the metabolite concentrations were different according to the ovulation status. However, our results do not provide evidence for the contribution of CYP2D6 polymorphism to either drug response or CC concentrations.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Vause TD / 2010 / Ovulation induction in polycystic ovary syndrome: No. 242, May 2010 / Int J Gynaecol Obstet 111:95~100
구윤희 / 2010 / 다낭성난소증후군 환자의 불임치료 / Obstetrics & Gynecology Science 53(10):869~880
Nasseri S / 2001 / Clomiphene citrate in the twenty-first century / Hum Fertil (Camb) 4:145~151
Mürdter TE / 2012 / Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites / Hum Mol Genet 21:1145~1154
Ganchev B / 2011 / Quantification of clomiphene metabolite isomers in human plasma by rapid-resolution liquid chromatography-electrospray ionization-tandem mass spectrometry / Anal Bioanal Chem 400:3429~3441
구윤희 / 2010 / 다낭성난소증후군 환자의 불임치료 / Obstetrics & Gynecology Science 53(10):869~880
Nasseri S / 2001 / Clomiphene citrate in the twenty-first century / Hum Fertil (Camb) 4:145~151
Mürdter TE / 2012 / Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites / Hum Mol Genet 21:1145~1154
Ganchev B / 2011 / Quantification of clomiphene metabolite isomers in human plasma by rapid-resolution liquid chromatography-electrospray ionization-tandem mass spectrometry / Anal Bioanal Chem 400:3429~3441
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