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논문 기본 정보

자료유형
학술저널
저자정보
Je Wook Kang (Department of Gastroenterology Ajou University School of Medicine Suwon Gyeonggi-do Korea) Dae Kyeong Han (Laboratory Animal Research Center Ajou University School of Medicine Suwon Gyeonggi-do Korea) Ock Nyun Kim (Laboratory Animal Research Center Ajou University School of Medicine Suwon Gyeonggi-do Korea) Kwang Jae Lee (Department of Gastroenterology Ajou University School of Medicine Suwon Gyeonggi-do Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.22 No.2
발행연도
2016.1
수록면
304 - 309 (6page)

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Background/AimsDA-9701 is a novel prokinetic agent. In the present study, we investigated the effect of DA-9701 on the motility of the gastric antrumin the normal and clonidine-induced hypomotility in an in vivo animal model. MethodsA strain gauge force transducer was sutured on the gastric antrum to measure the contractile activity in rats. A total of 28 rats weresubclassified into the 4 groups: (1) the placebo group, (2) the DA-9701 group, (3) the placebo group in the clonidine-pretreated rats,and (4) the DA-9701 group in the clonidine-pretreated rats. After the basal recording, either placebo (3% [w/v] hydroxypropylmethylcellulose) or DA-9701 was administered. Contractile signals were measured after the administration and after a meal. In the clonidinepretreatedrats, either placebo or DA-9701 was administered. Contractile signals were measured after the administration and after ameal. ResultsOral administration of DA-9701 did not significantly alter the motility index of the gastric antrum in the preprandial and postprandialperiods, compared with the placebo group. The administration of clonidine decreased the motility index of the gastric antrum inthe preprandial and postprandial periods, compared with the administration of placebo. This reduction of the antral motility by theadministration of clonidine was not observed in the clonidine-pretreated DA-9701 group. The percentage of the motility index in thepostprandial period was significantly greater in the clonidine-pretreated DA-9701 group, compared with the clonidine-pretreatedplacebo group. ConclusionsDA-9701 improves the hypomotility of the gastric antrum induced by clonidine, suggesting its gastroprokinetic effect in thepathologic condition.

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