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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제5호
- 발행연도
- 2017.9
- 수록면
- 495 - 507 (13page)
이용수
초록· 키워드
오류제보하기
The effect of clonidine administered intrathecally (i.t.) on the mortality and the blood glucose level induced by sepsis was examined in mice. To produce sepsis, the mixture of D-galactosamine (GaLN; 0.6 g/10 ml)/lipopolysaccharide (LPS; 27 μg/27 μl) was treated intraperitoneally (i.p.). The i.t. pretreatment with clonidine (5 μg/5 μl) increased the blood glucose level and attenuated mortality induced by sepsis in a dose-dependent manner. The i.t. post-treatment with clonidine up to 3 h caused an elevation of the blood glucose level and protected sepsis-induced mortality, whereas clonidine post-treated at 6, 9, or 12 h did not affect. The pre-treatment with oral D-glucose for 30 min prior to i.t. post-treatment (6 h) with clonidine did not rescue sepsis-induced mortality. In addition, i.t. pretreatment with pertussis toxin (PTX) reduced clonidine-induced protection against mortality and clonidine-induced hyperglycemia, suggesting that protective effect against sepsis-induced mortality seems to be mediated via activating PTX-sensitive G-proteins in the spinal cord.
Moreover, pretreatment with clonidine attenuated the plasma tumor necrosis factor α (TNF-α) induced by sepsis. Clonidine administered i.t. or i.p. increased p-AMPKα1 and p-AMPKα2, but decreased p-Tyk2 and p-mTOR levels in both control and sepsis groups, suggesting that the up-regulations of p-AMPKα1 and p-AMPKα2, or downregulations of p-mTOR and p-Tyk2 may play critical roles for the protective effect of clonidine against sepsis-induced mortality.
목차
등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
Levi M / 2008 / Sepsis, coagulation, and antithrombin : old lessons and new insights / Semin Thromb Hemost 34:742~746
van Westerloo DJ / 2005 / The cholinergic antiinflammatory pathway regulates the host response during septic peritonitis / J Infect Dis 191:2138~2148
Schouten M / 2008 / Inflammation, endothelium, and coagulation in sepsis / J Leukoc Biol 83:536~545
Dünser MW / 2008 / Arginine vasopressin in vasodilatory shock : effects on metabolism and beyond / Curr Opin Anaesthesiol 21:122~127
Lang CH / 1992 / Sepsis-induced insulin resistance in rats is mediated by a beta-adrenergic mechanism / Am J Physiol 263:E703~E711
van Westerloo DJ / 2005 / The cholinergic antiinflammatory pathway regulates the host response during septic peritonitis / J Infect Dis 191:2138~2148
Schouten M / 2008 / Inflammation, endothelium, and coagulation in sepsis / J Leukoc Biol 83:536~545
Dünser MW / 2008 / Arginine vasopressin in vasodilatory shock : effects on metabolism and beyond / Curr Opin Anaesthesiol 21:122~127
Lang CH / 1992 / Sepsis-induced insulin resistance in rats is mediated by a beta-adrenergic mechanism / Am J Physiol 263:E703~E711
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