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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 40 - 47 (8page)
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초록· 키워드
오류제보하기
Myasthenia gravis (MG) is an antibody-mediated autoimmune disease characterized by exertional weakness. There is no biomarker to reflect disease activity and guide treatment decision. Here, we reported a pilot blood transcriptome study using RNA sequencing (RNA-seq) that identified differences of 5 samples in active status and 5 in remission from 8 different patients and 2 patients provided samples for both active and remission phase. We found a total of 28 differentially expressed genes (DEGs) possibly related to disease activity (23 up-regulated and 5 down-regulated). The DEGs were enriched for the cell motion and cell migration processes in which included were ICAM1, CCL3, S100P and GAB2. The apoptosis and cell death pathway was also significantly enriched, which includes NFKBIA, ZC3H12A, TNFAIP3, and PPP1R15A. Our result suggests that transcript abundance
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참고문헌 (30)
참고문헌 신청
Berrih-Aknin S / 2014 / Myasthenia gravis:a comprehensive review of immune dysregulation and etiological mechanisms / J Autoimmun 52:90~100
McConville J / 2004 / Detection and characterization of MuSK antibodies in seronegative myasthenia gravis / Ann Neurol 55:580~584
Berrih-Aknin S / 2014 / Diagnostic and clinical classification of autoimmune myasthenia gravis / J Autoimmun 48-49:143~148
Evoli A / 2003 / Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis / Brain 126:2304~2311
Heldal AT / 2014 / Repeated acetylcholine receptor antibody-concentrations and association to clinical myasthenia gravis development / PLoS One 9:e114060
McConville J / 2004 / Detection and characterization of MuSK antibodies in seronegative myasthenia gravis / Ann Neurol 55:580~584
Berrih-Aknin S / 2014 / Diagnostic and clinical classification of autoimmune myasthenia gravis / J Autoimmun 48-49:143~148
Evoli A / 2003 / Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis / Brain 126:2304~2311
Heldal AT / 2014 / Repeated acetylcholine receptor antibody-concentrations and association to clinical myasthenia gravis development / PLoS One 9:e114060
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