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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 99 - 110 (12page)
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초록· 키워드
오류제보하기
Ischemia-reperfusion injury (IRI) is an inevitable consequence of organ transplantation that has major consequences for graft-and patient survival. During transplantation procedures, allografts are exposed to various periods of complete ischemia. Ischemic insult starts with brain death, and its associated hemodynamic disturbances continue during donor organ procurement, cold preservation, and implantation. Ischemia-reperfusion injury, which is a risk factor for acute graft injury, delayed graft function, and acute and chronic rejection, is triggered following reperfusion. Along the cascade of pathogenic events that accompany ischemic insults and cause IRI, there has been an appreciation for various immune mechanisms within the allograft itself. The pathophysiological events associated with IRI originate in signals derived from pattern recognition receptors (PRRs) expressed in the donor organ. Danger associated molecular patterns (DAMP) released from injured cells serve as ligands for PRRs expressed on many cells in the donor organ. Activation of PRR signaling in the donor organ leads to production of proinflammatory cytokines and activates the innate immune system, triggering adaptive immune responses as well as cell death signaling, ultimately worsening the initial ischemic injury. Accordingly, deciphering the inflammatory pathway of innate immunity in IRI may provide a good therapeutic target to block acute sterile inflammation caused by tissue damage.
목차
등록된 정보가 없습니다.
참고문헌 (113)
참고문헌 신청
Johnson KJ / 1993 / Postischemic renal injury due to oxygen radicals / Curr Opin Nephrol Hypertens 2:625~635
Perico N / 2004 / Delayed graft function in kidney transplantation / Lancet 364:1814~1827
Kosieradzki M / 2008 / Ischemia/reperfusion injury in kidney transplantation : mechanisms and prevention / Transplant Proc 40:3279~3288
Ali S / 2013 / Biomarkers of acute injury : predicting the long-term outcome after transplantation / Kidney Int 84:1072~1074
Gjertson DW / 2000 / Living unrelated donor kidney transplantation / Kidney Int 58:491~499
Perico N / 2004 / Delayed graft function in kidney transplantation / Lancet 364:1814~1827
Kosieradzki M / 2008 / Ischemia/reperfusion injury in kidney transplantation : mechanisms and prevention / Transplant Proc 40:3279~3288
Ali S / 2013 / Biomarkers of acute injury : predicting the long-term outcome after transplantation / Kidney Int 84:1072~1074
Gjertson DW / 2000 / Living unrelated donor kidney transplantation / Kidney Int 58:491~499
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