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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 919 - 925 (7page)
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Few studies have compared outcomes in patients undergoing liver transplantation (LT) for hepatitis B virus (HBV) and alcoholic liver disease (ALD) in Asian countries in which living donor LT (LDLT) is dominant, where HBV is endemic and where there are no strict regulations on pre-transplant abstinence for ALD. This study compared post-LT outcomes of deceased donor LT (DDLT) in patients with ALD and HBV. Data from 220 patients who underwent primary DDLT at Seoul National University Hospital from January 2010 to December 2014, including 107 with HBV and 38 with ALD, were retrospectively analyzed. Seventy-four patients (69.2%) in the HBV group and 30 (78.9%) in the ALD group had United Network for Organ Sharing (UNOS) status 2A (P = 0.250). There were no significant differences in their 1-year (90.7% vs. 92.1%) and 3-year (82.1% vs. 82.3%) overall survival rates (P = 1.000). Multivariate analysis showed that high serum gamma glutamyltransferase concentration (≥ 70 IU/L) was independently prognostic of 1-year post-LT overall survival. Survival outcomes following DDLT were similar in Korean patients with ALD and HBV, even in the absence of strict pre-transplant abstinence from alcohol as a selection criterion.
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참고문헌 (33)
참고문헌 신청
Tome S / 2003 / Timing of liver transplantation in alcoholic cirrhosis / J Hepatol 39:302~307
Shah VH / 2015 / Managing alcoholic liver disease / Clin Mol Hepatol 21:212~219
Burra P / 2010 / Liver transplantation for alcoholic liver disease in Europe : a study from the ELTR(European Liver Transplant Registry) / Am J Transplant 10:138~148
Kim WR / 2015 / OPTN/SRTR 2013 Annual Data Report : liver / Am J Transplant 15(Suppl 2):1~28
Bellamy CO / 2001 / Liver transplantation for alcoholic cirrhosis : long term follow-up and impact of disease recurrence / Transplantation 72:619~626
Shah VH / 2015 / Managing alcoholic liver disease / Clin Mol Hepatol 21:212~219
Burra P / 2010 / Liver transplantation for alcoholic liver disease in Europe : a study from the ELTR(European Liver Transplant Registry) / Am J Transplant 10:138~148
Kim WR / 2015 / OPTN/SRTR 2013 Annual Data Report : liver / Am J Transplant 15(Suppl 2):1~28
Bellamy CO / 2001 / Liver transplantation for alcoholic cirrhosis : long term follow-up and impact of disease recurrence / Transplantation 72:619~626
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Pathophysiology and Management of Alcoholic Liver Disease: Update 2016
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Patients Who Received Liver Transplantation
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