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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 10 - 17 (8page)
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The production of red blood cells, termed erythropoiesis, occurs in two waves in the developing mouse embryo: first primitive erythropoiesis followed by defin-itive erythropoiesis. In the mouse embryo, both primitive and definitive eryth-ropoiesis originates in the extra-embryonic yolk sac. The definitive wave then mi-grates to the fetal liver, fetal spleen and fetal bone marrow as these organs form. The fetal liver serves as the major organ for hematopoietic cell expansion and er-ythroid maturation after mid-gestation. The erythropoietic niche, which ex-presses critical cytokines such as stem cell factor (SCF), thrombopoietin (TPO) and the insulin-like growth factors IGF1 and IGF2, supports hematopoietic ex-pansion in the fetal liver. Previously, our group demonstrated that DLK1+ hepato-blasts support fetal liver hematopoiesis through erythropoietin and SCF release as well as extracellular matrix deposition. Loss of DLK1+ hepatoblasts in Map2k4-/- mouse embryos resulted in decreased numbers of hematopoietic cells in fetal liver. Genes encoding proteinases and peptidases were found to be highly expressed in DLK1+ hepatoblasts. Capitalizing on this knowledge, and working on the assumption that these proteinases and peptidases are generating small, potentially biologically active peptides, we assessed a range of peptides for their ability to support erythropoiesis in vitro. We identified KS-13 (PCT/JP2010/ 067011) as an erythropoietic peptide-a peptide which enhances the production of red blood cells from progenitor cells. Here, we discuss the elements regulating embryonic erythropoiesis with special attention to niche cells, and demonstrate how this knowledge can be applied in the identification of niche-derived peptides with potential therapeutic capability.
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참고문헌 (68)
참고문헌 신청
Al-Drees MA / 2015 / Making blood : the haematopoietic niche throughout ontogeny / Stem Cells Int 2015:571893
Palis J / 1999 / Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse / Development 126:5073~5084
Tavian M / 2005 / Embryonic development of the human hematopoietic system / Int J Dev Biol 49:243~250
Swain A / 2014 / Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver / Histol Histopathol 29:1077~1082
Tanaka Y / 2015 / Embryonic hematopoietic progenitor cells reside in muscle before bone marrow hematopoiesis / PLoS One 10:e0138621
Palis J / 1999 / Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse / Development 126:5073~5084
Tavian M / 2005 / Embryonic development of the human hematopoietic system / Int J Dev Biol 49:243~250
Swain A / 2014 / Intrinsic and extrinsic regulation of mammalian hematopoiesis in the fetal liver / Histol Histopathol 29:1077~1082
Tanaka Y / 2015 / Embryonic hematopoietic progenitor cells reside in muscle before bone marrow hematopoiesis / PLoS One 10:e0138621
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