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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 274 - 278 (5page)
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BackgroundCharacterization of the ABO blood group at the phenotype and genotype levels is clinically essential for transfusion, forensics, and population studies. This study elucidated ABO phenotypes and genotypes, and performed an evaluation of their distribution in in-dividuals from the western region of Saudi Arabia.MethodsOne-hundred and seven samples underwent standard serological techniques for ABO blood group phenotype analysis. ABO alleles and genotypes were identified using multi-plex polymerase chain reaction, and electrophoretic analysis was performed to evaluate the highly polymorphic ABO locus.ResultsA phenotype distribution of 37.4%, 30.8%, 24.3%, and 7.5% was found for blood groups O, A, B, and AB respectively in our study cohort. Genotype analysis identified 10 genotype combinations with the O01/O02 and A102/O02 genotypes being the most frequent with frequencies of 33.6% and 14.95%, respectively. Common genotypes such as A101/A101, A101/A102, A101/B101, B101/B101, and O01/O01 were not detected. Similarly, the rare genotypes, cis-AB01/O02, cis-AB01/O01, and cis-AB01/A102 were not found in our cohort. The most frequently observed allele was O02 (35.98%) followed by the A102 allele (17.76%). Furthermore, our findings are discussed in reference to ABO allele and geno-type frequencies found in other ethnic groups.ConclusionThe study has a significant implication on the management of blood bank and transfusion services in Saudi Arabian patients.
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참고문헌 (24)
참고문헌 신청
Chen YJ / 2006 / Novel polymorphisms in exons 6 and 7 of A/B alleles detected by polymerase chain reaction-single strand conformation polymorphism / Vox Sang 90:119~127
Blumenfeld OO / 2004 / Allelic genes of blood group antigens:a source of human mutations and cSNPs documented in the Blood Group Antigen Gene Mutation Database / Hum Mutat 23:8~16
Olsson ML / 2001 / Polymorphism and recombination events at the ABO locus: a major challenge for genomic ABO blood grouping strategies / Transfus Med 11:295~313
Ray S / 2014 / Molecular genotyping of ABO blood groups in some population groups from India / Indian J Med Res 139:105~111
Zhu F / 2010 / Distribution of ABO blood group allele and identification of three novel alleles in the Chinese Han population / Vox Sang 98:554~559
Blumenfeld OO / 2004 / Allelic genes of blood group antigens:a source of human mutations and cSNPs documented in the Blood Group Antigen Gene Mutation Database / Hum Mutat 23:8~16
Olsson ML / 2001 / Polymorphism and recombination events at the ABO locus: a major challenge for genomic ABO blood grouping strategies / Transfus Med 11:295~313
Ray S / 2014 / Molecular genotyping of ABO blood groups in some population groups from India / Indian J Med Res 139:105~111
Zhu F / 2010 / Distribution of ABO blood group allele and identification of three novel alleles in the Chinese Han population / Vox Sang 98:554~559
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