Phosphodiesterase type 5 inhibitor administered immediately after radical prostatectomy temporarily increases the need for incontinence pads, but improves final continence status

Yasuhiro Kaiho; Shinichi Yamashita; Akihiro Ito; Yoshihide Kawasaki; Hideaki Izumi; Naoki Kawamorita; Hisanobu Adachi; Koji Mitsuzuka; Yoichi Arai

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자료유형: 학술저널

저자정보: Yasuhiro Kaiho (Tohoku University Graduate School of Medicine) Shinichi Yamashita (Tohoku University Graduate School of Medicine) Akihiro Ito (Tohoku University Graduate School of Medicine) Yoshihide Kawasaki (Tohoku University Graduate School of Medicine) Hideaki Izumi (Tohoku University Graduate School of Medicine) Naoki Kawamorita (Tohoku University Graduate School of Medicine) Hisanobu Adachi (Tohoku University Graduate School of Medicine) Koji Mitsuzuka (Tohoku University Graduate School of Medicine) Yoichi Arai (Tohoku University Graduate School of Medicine)

저널정보: 대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.57 No.5

발행연도: 2016.1

수록면: 357 - 363 (7page)

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Purpose: To evaluate the effects of phosphodiesterase type 5 inhibitor (PDE5i) on urinary continence recovery after bilateral nerve-sparing radical prostatectomy (BNSRP). Materials and Methods: Between 2002 and 2012, 137 of 154 consecutive patients who underwent BNSRP in our institution retrospectively divided into 3 groups that included patients taking PDE5i immediately after surgery (immediate PDE5i group, n=41), patients starting PDE5i at an outpatient clinic after discharge (PDE5i group, n=56), and patients taking no medication (non-PDE5i group, n=40). Using self-administered questionnaires, the proportion of patients who did not require incontinence pads (pad-free patients) was calculated preoperatively and at 1, 3, 6, 12, 18, and 24 months after BNSRP. Severity of incontinence was determined based on the pad numbers and then compared among the 3 groups. Results: Proportions of pad-free patients and severity of incontinence initially deteriorated in all of the groups to the lowest values soon after undergoing BNSRP, with gradual improvement noted thereafter. The deterioration was most prominent in the immediate PDE5i group. As compared to the non-PDE5i group, both the PDE5i and immediate PDE5i groups exhibited a better final continence status. Conclusions: PDE5i improves final continence status. However, administration of PDE5i immediately after surgery causes a distinct temporary deterioration in urinary incontinence.

참고문헌 (20)

참고문헌 신청

Kaiho Y / 2016 / Urinary straining contributes to inguinal hernia after radical retropubic prostatectomy / Int J Urol 23:478~483

Kaiho Y / 2013 / Optimization of sexual function outcome after radical prostatectomy using phosphodiesterase type 5 inhibitors / Int J Urol 20:285~289

Namiki S / 2014 / Long-term quality of life after radical prostatectomy: 8-year longitudinal study in Japan / Int J Urol 21:1220~1226

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