Differences Regarding the Molecular Features and Gut Microbiota Between Right and Left Colon Cancer

김광민; Ernes John T. Castro; 심홍진; John Vincent G. Advincula; 김영완

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저자정보: 김광민 (연세대학교 원주의과대학 외과학교실) Ernes John T. Castro (The Medical City) 심홍진 (연세대학교 원주의과대학) John Vincent G. Advincula (Amang Memorial Rodriguez Medical Center) 김영완 (연세대학교)

저널정보: 대한대장항문학회 Annals of Coloproctology Annals of Coloproctolgy Vol.34 No.6

발행연도: 2018.1

수록면: 280 - 285 (6page)

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For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.

참고문헌 (47)

참고문헌 신청

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정명규 / 2017 / Is the Location of the Tumor Another Prognostic Factor for Patients With Colon Cancer? / Annals of Coloproctolgy 33(6):210~218

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