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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 270 - 281 (12page)
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Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyruvate oxidation after glycolysis and fuels the Krebs cycle to meet energy demands. Fine-tuning of PDC activity has been mainly attributed to post-translational modifications of its subunits, including the extensively studied phosphorylation and de-phosphorylation of the E1α subunit of pyruvate dehydrogenase (PDH), modulated by kinases (pyruvate dehydrogenase kinase [PDK] 1-4) and phosphatases (pyruvate dehydrogenase phosphatase [PDP] 1-2), respectively. In addition to phosphorylation, other covalent modifications, including acetylation and succinylation, and changes in metabolite levels via metabolic pathways linked to utilization of glucose, fatty acids, and amino acids, have been identified. In this review, we will summarize the roles of PDC in diverse tissues and how regulation of its activity is affected in various metabolic disorders.
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참고문헌 (60)
참고문헌 신청
Stacpoole PW / 2012 / The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases / Aging Cell 11:371~377
Jeoung NH / 2014 / Regulation of pyruvate metabolism in metabolic-related diseases / Rev Endocr Metab Disord 15:99~110
Muoio DM / 2012 / Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility / Cell Metab 15:764~777
Kankotia S / 2014 / Dichloroacetate and cancer: new home for an orphan drug? / Biochim Biophys Acta 1846:617~629
Sutendra G / 2014 / A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation / Cell 158:84~97
Jeoung NH / 2014 / Regulation of pyruvate metabolism in metabolic-related diseases / Rev Endocr Metab Disord 15:99~110
Muoio DM / 2012 / Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility / Cell Metab 15:764~777
Kankotia S / 2014 / Dichloroacetate and cancer: new home for an orphan drug? / Biochim Biophys Acta 1846:617~629
Sutendra G / 2014 / A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation / Cell 158:84~97
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