지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 493 - 499 (7page)
이용수
초록· 키워드
오류제보하기
Aspects of autoimmune thyroid disease updated in this review include: immunoglobulin G4 (IgG4)-related thyroid disease (Riedel’sthyroiditis, fibrosing variant of Hashimoto’s thyroiditis, IgG4-related Hashimoto’s thyroiditis, and Graves’ disease with elevatedIgG4 levels); recent epidemiological studies from China and Denmark indicating that excess iodine increases the incidence of Hashimoto’sthyroiditis and hypothyroidism; immunomodulatory agents (ipilimumab, pembrolizumab, nivolumab) activate immune responseby inhibiting T-cell surface receptors which down-regulate immune response, i.e., cytotoxic T-lymphocyte antigen 4 and programmedcell death protein 1 pathways; alemtuzumab is a humanised monoclonal antibody to CD52 which causes immune depletionand thyroid autoimmune disease especially Graves’ hyperthyroidism; small molecule ligand (SML) agonists which activate receptors,SML neutral antagonists, which inhibit receptor activation by agonists, and SML inverse agonists which inhibit receptor activationby agonists and inhibit constitutive agonist independent signaling have been identified. SML antagonism of thyroid-stimulatinghormone-receptor stimulatory antibody could treat Graves’ hyperthyroidism and Graves’ ophthalmopathy; and thyroxinetreatment of subclinical hypothyroidism can produce iatrogenic subclinical hyperthyroidism with the risk of atrial fibrillation and osteoporosis. The increased risk of harm from subclinical hyperthyroidism may be stronger than the potential benefit from treatment ofsubclinical hypothyroidism.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Stone JH / 2012 / Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations / Arthritis Rheum 64:3061~3067
Hamano H / 2001 / High serum IgG4 concentrations in patients with sclerosing pancreatitis / N Engl J Med 344:732~738
Dahlgren M / 2010 / Riedel’s thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum / Arthritis Care Res (Hoboken) 62:1312~1318
Tabata T / 2011 / Serial changes of elevated serum IgG4 levels in IgG4-related systemic disease / Intern Med 50:69~75
Kawa S / 2002 / HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population / Gastroenterology 122:1264~1269
Hamano H / 2001 / High serum IgG4 concentrations in patients with sclerosing pancreatitis / N Engl J Med 344:732~738
Dahlgren M / 2010 / Riedel’s thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum / Arthritis Care Res (Hoboken) 62:1312~1318
Tabata T / 2011 / Serial changes of elevated serum IgG4 levels in IgG4-related systemic disease / Intern Med 50:69~75
Kawa S / 2002 / HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population / Gastroenterology 122:1264~1269
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