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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 225 - 233 (9page)
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초록· 키워드
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Prostate cancer is known as the fifth most common cancer in Korean male. The etiology of the prostate cancer remains unknown, but age, race, drug, family history, dietary habit and steroid hormone levels have been suggested as causative factors. Among these factors, variations in androgen hormone levels have been suggested as one of risk factors for the cancer. The glucuronidation is a major pathway of detoxification process of toxin and hormones within human body by UDP-glucuronosyltransferase (UGT) enzymes. Known as the androgen inactivating UGT2B enzyme family, UGT2B17 and UGT2B28 have common deletion region by copy number variation (CNV) and UGT2B15 has a single nucleotide polymorphism (SNP) (rs1902023: G[T) locus which contains the change from Asp to Tyr on exon 1. These polymorphisms were analyzed with genomic DNA extracted from 555 prostate cancer cases and 404 control males. There was no difference in the frequency of CNV and SNP of each UGT2B genes between prostate cancer cases and control males. In this study, we found the decreased risk (OR, 0.39; 95 % CI, 0.19–0.83; P = 0.011) of prostate cancer in individuals with UGT2B17 del/del type, UGT2B28 in/del type and UGT2B15 SNP TT type. Additionally, we found the length polymorphisms of the short tandem repeat (STR) in the allelic loci of UGT2B28 deletion regions and suggest that this locus can be used for a personal identification marker.
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참고문헌 (37)
참고문헌 신청
Abildskov K / 2010 / Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine / Drug Metab Dispos 38:545~553
Barbier O / 2008 / Inactivation of androgens by UDPglucuronosyltransferases in the human prostate / Best Pract Res Clin Endocrinol Metab 22:259~270
Beaulieu M / 1996 / Isolation and characterization of a novel cDNA encoding a human UDPglucuronosyltransferase active on C19 steroids / J Biol Chem 271:22855~22862
Belanger A / 1998 / Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues / J Steroid Biochem Mol Biol 65:301~310
Belanger A / 2003 / Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans / Trends Endocrinol Metab 14:473~479
Barbier O / 2008 / Inactivation of androgens by UDPglucuronosyltransferases in the human prostate / Best Pract Res Clin Endocrinol Metab 22:259~270
Beaulieu M / 1996 / Isolation and characterization of a novel cDNA encoding a human UDPglucuronosyltransferase active on C19 steroids / J Biol Chem 271:22855~22862
Belanger A / 1998 / Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues / J Steroid Biochem Mol Biol 65:301~310
Belanger A / 2003 / Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans / Trends Endocrinol Metab 14:473~479
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