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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제4호
- 발행연도
- 2020.1
- 수록면
- 604 - 614 (11page)
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초록· 키워드
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The application of steroids has steadily increased thanks to their therapeutic effects. However, alternatives are required due their severe side effects; thus, studies on the activities of steroid derivatives are underway. Sugar derivatives of nandrolone, which is used to treat breast cancer, as well as cortisone and prednisone, which reduce inflammation, pain, and edema, are unknown. We linked O-glucose to nandrolone and testosterone using UDP-glucosyltransferase (UGT-1) and, then, tested their bioactivities in vitro. Analysis by NMR showed that the derivatives were 17β-nandrolone β-D-glucose and 17β-testosterone β-D-glucose, respectively. The viability was higher and cytotoxicity was evident in PC12 cells incubated with rotenone and, testosterone derivatives, compared to the controls. SH-SY5Y cells incubated with H2O2 and nandrolone derivatives remained viable and cytotoxicity was attenuated. Both derivatives enhanced neuronal protective effects and increased the amounts of cellular ATP.
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참고문헌 (50)
참고문헌 신청
Stanworth RD / 2008 / Testosterone for the aging male; current evidence and recommended practice / Clin. Interv. Aging 3:25~44
McBride JA / 2016 / Testosterone deficiency in the aging male / Ther. Adv. Urol 8:47~60
Kandeel FR / 2001 / Male sexual function and its disorders : physiology, pathophysiology, clinical investigation, and treatment / Endocr. Rev 22:342~388
Yeap BB / 2009 / Testosterone and ill-health in aging men / Nat. Clin. Pract. Endocrinol. Metab 5:113~121
McMahon CG / 2017 / Pharmacokinetics, clinical efficacy, safety profile, and patient-reported outcomes in patients receiving subcutaneous testosterone pellets 900 mg for treatment of symptoms associated with androgen deficiency / J. Sex. Med 14:883~890
McBride JA / 2016 / Testosterone deficiency in the aging male / Ther. Adv. Urol 8:47~60
Kandeel FR / 2001 / Male sexual function and its disorders : physiology, pathophysiology, clinical investigation, and treatment / Endocr. Rev 22:342~388
Yeap BB / 2009 / Testosterone and ill-health in aging men / Nat. Clin. Pract. Endocrinol. Metab 5:113~121
McMahon CG / 2017 / Pharmacokinetics, clinical efficacy, safety profile, and patient-reported outcomes in patients receiving subcutaneous testosterone pellets 900 mg for treatment of symptoms associated with androgen deficiency / J. Sex. Med 14:883~890
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