지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1 - 13 (13page)
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Background: Sarcopenia is associated with a poor prognosis in patients with liver cirrhosis. However, it is not known whether the rate of skeletal muscle depletion is also associated with a poor prognosis. We investigated the prognostic impact of the rate of skeletal muscle depletion in patients with liver cirrhosis. Methods: We included retrospectively all patients with liver cirrhosis who underwent both multiple computed tomography scans and hepatic venous pressure gradient (HVPG) measurements. Results: A total of 131 patients with liver cirrhosis were enrolled. The mean age of the patients was 53.7 years and alcoholic liver disease was the most common cause (61.8%). Sixty-four patients (48.9%) were diagnosed with sarcopenia. The median changes in skeletal muscle area per year (ΔSMA/y) were −0.89%. During a median follow-up period of 46.2 months (range, 3.4–87.6), 45 patients (34.4%) died. In multivariate analyses, age, Child- Pugh score, HVPG, presence of sarcopenia and ΔSMA/y were independently associated with mortality. Cumulative mortality was significantly higher in patients with ΔSMA/y < −2.4% than those with ΔSMA/y ≥ −2.4% (log-rank test, P < 0.001). Conclusion: Both the presence and rate of change of sarcopenia are independently associated with long-term mortality in patients with liver cirrhosis.
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참고문헌 (40)
참고문헌 신청
Cederholm T / 2017 / ESPEN guidelines on definitions and terminology of clinical nutrition / Clin Nutr 36(1):49~64
Santilli V / 2014 / Clinical definition of sarcopenia / Clin Cases Miner Bone Metab 11(3):177~180
Shachar SS / 2016 / Prognostic value of sarcopenia in adults with solid tumours: a meta-analysis and systematic review / Eur J Cancer 57:58~67
van Vugt JL / 2016 / Systematic review and meta-analysis of the impact of computed tomography-assessed skeletal muscle mass on outcome in patients awaiting or undergoing liver transplantation / Am J Transplant 16(8):2277~2292
Anker SD / 2016 / Welcome to the ICD-10 code for sarcopenia / J Cachexia Sarcopenia Muscle 7(5):512~514
Santilli V / 2014 / Clinical definition of sarcopenia / Clin Cases Miner Bone Metab 11(3):177~180
Shachar SS / 2016 / Prognostic value of sarcopenia in adults with solid tumours: a meta-analysis and systematic review / Eur J Cancer 57:58~67
van Vugt JL / 2016 / Systematic review and meta-analysis of the impact of computed tomography-assessed skeletal muscle mass on outcome in patients awaiting or undergoing liver transplantation / Am J Transplant 16(8):2277~2292
Anker SD / 2016 / Welcome to the ICD-10 code for sarcopenia / J Cachexia Sarcopenia Muscle 7(5):512~514
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