Expression and Prognostic Implications of FOXO3a and Ki67 in Lung Adenocarcinomas

Liu, Hong-Bin; Gao, Xiang-Xiang; Zhang, Qing; Liu, Jian; Cui, Yuan; Zhu, Yan; Liu, Yi-Fei

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자료유형: 학술저널

저자정보: Liu, Hong-Bin (Department of Pathology, The First People's Hospital of Nantong) Gao, Xiang-Xiang (Department of Oncology, Nantong University Cancer Hospital) Zhang, Qing (Department of Pathology, Affiliated Hospital of Nantong University) Liu, Jian (Department of Oncology, Affiliated Hospital of Nantong University) Cui, Yuan (Department of Pathology, Affiliated Hospital of Nantong University) Zhu, Yan (Department of Pathology, The First People's Hospital of Nantong) Liu, Yi-Fei (Department of Pathology, Affiliated Hospital of Nantong University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제4호

발행연도: 2015.1

수록면: 1,443 - 1,448 (6page)

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To investigate the significance of FOXO3a and Ki67 in human lung adenocarcinomas. Envision immunohistochemical staining and Western blotting were used to examine the protein expression of FOXO3a in 127 cases of human lung adenocarcinoma specimens. The positive rate in lung adenocarcinoma (55.9%) was lower than that in normal tissues (80%). We found that the expression of FOXO3a was closely related with the degree of differentiation, TNM staging, lymph node metastasis and survival. In addition, significant differences in the different pathological types of lung adenocarcinoma cases (P<0.01). The FOXO3a positive rate of the acini as the main type (APA) (86.7%) and the lepidic as the main type (LPA) (82.4%) was higher than the solid as the main type (SPA) (50.0%), the papilla as the main type (PPA) (42.9%) and the micropapilla as the main type (MPA) (9.4%). Moreover, the expression of FOXO3a was negatively related with Ki67 expression. Our results suggested that the expression of FOXO3a is closely correlated with the aggressiveness of lung adenocarcinoma. It was indicated that disregulation of FOXO3a might play key roles in the occurrence and development of lung a denocarcinoma and joint detection of the two markers might play an important role in diagnosing tumors.

#FOXO3a #Ki67 #lung adenocarcinoma #prognosis

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Liu, Hong-Bin

소속기관 Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine