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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,726 - 1,734 (9page)
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The neurocognitive function and quality of life of 58 Korean survivors of childhood medulloblastoma were assessed after surgery, cranial radiation and chemotherapy. All patients were evaluated with a battery of neurocognitive function tests and the Pediatric Functional Assessment of Cancer Therapy-Brain Tumor Survivors, which consists of self-report questionnaires on quality of life. The mean full-scale intelligence quotient (IQ), verbal IQ, and performance IQ scores were 90.2, 97.1, and 84.16, respectively. The mean memory quotient (MQ) score was 86.78, which was within 1 standard deviation of the average score of 100. Processing speed, attention, and executive function showed mild to moderate deficits. Intelligence, memory, executive function, visuospatial function, and simple motor function were significantly lower in the patients diagnosed before 8 years of age compared with those diagnosed after 8. The cognitive deficits in the patients diagnosed at younger ages might be related to earlier exposure to craniospinal irradiation and chemotherapy. The patient and parent proxy evaluations of attention, fine motor function, and quality of life did not differ. We found significant neurocognitive changes in a wide range of neurocognitive functional domains in Korean survivors of childhood medulloblastoma. Long-term follow-up studies of survivors of childhood medulloblastoma beginning at the time of their first diagnosis are required to better understand the deficits exhibited by survivors of childhood medulloblastoma, so that intervention strategies and treatment refinements that reduce the long-term neurocognitive decline can be developed.
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참고문헌 (30)
참고문헌 신청
Spiegler BJ / 2004 / Change in neurocognitive functioning after treatment with cranial radiation in childhood / J Clin Oncol 22:706~713
Kieffer-Renaux V / 2005 / Therapeutic schedules influence the pattern of intellectual decline after irradiation of posterior fossa tumors / Pediatr Blood Cancer 45:814~819
Khong PL / 2006 / White matter anisotropy in post-treatment childhood cancer survivors : preliminary evidence of association with neurocognitive function / J Clin Oncol 24:884~890
Rønning C / 2005 / Persistent cognitive dysfunction secondary to cerebellar injury in patients treated for posterior fossa tumors in childhood / Pediatr Neurosurg 41:15~21
Maddrey AM / 2005 / Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma / J Neurooncol 72:245~253
Kieffer-Renaux V / 2005 / Therapeutic schedules influence the pattern of intellectual decline after irradiation of posterior fossa tumors / Pediatr Blood Cancer 45:814~819
Khong PL / 2006 / White matter anisotropy in post-treatment childhood cancer survivors : preliminary evidence of association with neurocognitive function / J Clin Oncol 24:884~890
Rønning C / 2005 / Persistent cognitive dysfunction secondary to cerebellar injury in patients treated for posterior fossa tumors in childhood / Pediatr Neurosurg 41:15~21
Maddrey AM / 2005 / Neuropsychological performance and quality of life of 10 year survivors of childhood medulloblastoma / J Neurooncol 72:245~253
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