지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,355 - 1,361 (7page)
이용수
초록· 키워드
오류제보하기
We conducted pharmacovigilance data mining for a β-lactam antibiotics, amoxicillin, and compare the adverse events (AEs) with the drug labels of 9 countries including Korea, USA, UK, Japan, Germany, Swiss, Italy, France, and Laos. We used the Korea Adverse Event Reporting System (KAERS) database, a nationwide database of AE reports, between December 1988 and June 2014. Frequentist and Bayesian methods were used to calculate disproportionality distribution of drug-AE pairs. The AE which was detected by all the three indices of proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC) was defined as a signal. The KAERS database contained a total of 807,582 AE reports, among which 1,722 reports were attributed to amoxicillin. Among the 192,510 antibiotics-AE pairs, the number of amoxicillin-AE pairs was 2,913. Among 241 AEs, 52 adverse events were detected as amoxicillin signals. Comparing the drug labels of 9 countries, 12 adverse events including ineffective medicine, bronchitis, rhinitis, sinusitis, dry mouth, gastroesophageal reflux, hypercholesterolemia, gastric carcinoma, abnormal crying, induration, pulmonary carcinoma, and influenza-like symptoms were not listed on any of the labels of nine countries. In conclusion, we detected 12 new signals of amoxicillin which were not listed on the labels of 9 countries. Therefore, it should be followed by signal evaluation including causal association, clinical significance, and preventability.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Klein JO / 2003 / Amoxicillin/clavulanate for infections in infants and children: past, present and future / Pediatr Infect Dis J 22:S139~S148
Gillies M / 2015 / Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication / CMAJ 187:E21~E31
Pechère JC / 2001 / Patients’ interviews and misuse of antibiotics / Clin Infect Dis 33(Suppl 3):S170~S173
Arias CA / 2015 / A new antibiotic and the evolution of resistance / N Engl J Med 372:1168~1170
Dore MP / 1998 / Amoxycillin resistance is one reason for failure of amoxycillin-omeprazole treatment of Helicobacter pylori infection / Aliment Pharmacol Ther 12:635~639
Gillies M / 2015 / Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication / CMAJ 187:E21~E31
Pechère JC / 2001 / Patients’ interviews and misuse of antibiotics / Clin Infect Dis 33(Suppl 3):S170~S173
Arias CA / 2015 / A new antibiotic and the evolution of resistance / N Engl J Med 372:1168~1170
Dore MP / 1998 / Amoxycillin resistance is one reason for failure of amoxycillin-omeprazole treatment of Helicobacter pylori infection / Aliment Pharmacol Ther 12:635~639
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