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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 200 - 207 (8page)
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Purpose: Cardiovascular adverse events (AEs) after use of dipeptidyl peptidase-4 (DPP4) inhibitors have been reported and suspectedsince the launch of DPP-4 inhibitors in 2006. However, few studies have investigated the association between cardiovascularAEs and DPP-4 inhibitors. The objective of this study is to detect the signals of cardiovascular AEs after use of DPP-4 inhibitorsby analyzing the Korea Institute of Drug Safety & Risk Management-Korea Adverse Event Reporting System Database (KIDS-KD). Materials and Methods: Data on the use of oral antidiabetic drugs from 2008 to 2016 were extracted from KIDS-KD, and analyzeddescriptively. Data mining was conducted by calculating three indices, which were proportional reporting ratios, reporting oddsratios, and information components, to detect signals from use of all oral antidiabetic drugs including DPP-4 inhibitors. Then, thesuspected adverse drug reactions (ADRs) were confirmed by signal detection, and drug label information between the KoreaMinistry of Food and Drug Safety and the U.S. Food and Drug Administration were compared. Results: Cardiovascular AEs after taking DPP-4 inhibitors were detected in only three (1.0%) out of a total of 307 AE reports. Twoof the three cardiovascular AEs were reported after using sitagliptin and one using gemiglipitin, but these were not statisticallysignificant. Conclusion: Analysis of spontaneous ADR reports data on the use of DPP-4 inhibitors could not showed the association betweenDPP-4 inhibitors and cardiovascular AEs, due to a small number of cardiovascular AEs reports.
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