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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 179 - 187 (9page)
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초록· 키워드
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Objective. Pulmonary hypertension (PH) develops frequently in connective tissue diseases (CTD) and is an important prognostic factor. The aim of this study was to assess the prevalence of PH in patients with CTD by non-invasive echocardiography and analyze the potential biomarkers for helping to detect PH. Methods. All Korean patients with CTD who had dyspnea on exertion or interstitial lung disease (ILD) were screened for PH with echocardiography and clinical data were collected from four hospitals. Results. Among 196 patients with CTD, 108 (55.1%) had ILD and 21 had PH defined as ＞40 mmHg. Of the 21 patients with PH, 10, 4, and 3 patients had systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease, respectively. There was no difference in the incidence of PH according to the presence of ILD; 12 patients (11.1%) with ILD had PH and 9 patients (10.2%) without ILD had PH. The results of the pulmonary function test, total cholesterol, red cell volume distribution width, alkaline phosphatase, and the New York Heart Association (NYHA) functional class III or IV differed significantly according to the presence of PH. In multiple regression analysis, NYHA functional class III or IV (odd ratio [OR]=7.3, p=0.009) and forced vital capacity (OR=0.97, p=0.043) were independent predictive factors of PH. Conclusion. PH is not associated with the presence of ILD in Korean patients with CTD. On the other hand, NYHA functional class III or IV and decreased forced vital capacity indicate the presence of PH in connective tissue disease.
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참고문헌 (40)
참고문헌 신청
Khanna D / 2013 / Recommendations for screening and detection of connective tissue disease-associated pulmonary arterial hypertension / Arthritis Rheum 65:3194~3201
Task Force for Diagnosis / 2009 / Guidelines for the diagnosis and treatment of pulmonary hypertension / Eur Respir J 34:1219~1263
Chung L / 2010 / Characterization of connective tissue disease-associated pulmonary arterial hypertension from REVEAL: identifying systemic sclerosis as a unique phenotype / Chest 138:1383~1394
Shahane A / 2013 / Pulmonary hypertension in rheumatic diseases: epidemiology and pathogenesis / Rheumatol Int 33:1655~1667
Vachiery JL / 2009 / Screening for pulmonary arterial hypertension in systemic sclerosis / Eur Respir Rev 18:162~169
Task Force for Diagnosis / 2009 / Guidelines for the diagnosis and treatment of pulmonary hypertension / Eur Respir J 34:1219~1263
Chung L / 2010 / Characterization of connective tissue disease-associated pulmonary arterial hypertension from REVEAL: identifying systemic sclerosis as a unique phenotype / Chest 138:1383~1394
Shahane A / 2013 / Pulmonary hypertension in rheumatic diseases: epidemiology and pathogenesis / Rheumatol Int 33:1655~1667
Vachiery JL / 2009 / Screening for pulmonary arterial hypertension in systemic sclerosis / Eur Respir Rev 18:162~169
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