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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 234 - 240 (7page)
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We examined the clinical relationship between human leukocyte antigen B27 (HLA-B27) and juvenile idiopathic arthritis (JIA). Additionally, we assessed the usefulness of the Assessment of SpondyloArthritis International Society (ASAS) criteria for diagnosing juvenile spondyloarthropathies (SpA). Methods. We retrospectively reviewed medical records of 239 patients with JIA classified according to the International League of Associations for Rheumatology (ILAR) classification to analyze the features of the joint involvement site. Results were correlated with the presence of HLA-B27. After that, we classified the 239 JIA patients according to the ASAS criteria to diagnose juvenile SpA. The relationship between the ASAS criteria and a diagnosis of juvenile SpA was analyzed by a chi-squared test. Results. Back pain was associated with HLA-B27 in boys (p=0.002) but not in girls (p=0.616). In both sexes, involvement of the small joints in the lower extremities was highly associated with HLA-B27 (p=0.001 for boys, p=0.021 for girls). In addition, HLA-B27 was associated with enthesitis (p=0.004 for boys, p=0.021 for girls). Eighty-seven (36.4%) patients with JIA fulfilled the ASAS criteria; 2 (0.8%) had axial SpA and 85 (35.6%) had peripheral SpA. HLA-B27 was the most significant factor for diagnosing juvenile SpA (sensitivity 80%, specificity 99.31%, positive likelihood ratio, 116). Conclusion. The ILAR criteria have some weaknesses for diagnosing HLA-B27-positive JIA patients in early stages. The use of the ASAS criteria for juvenile patients will enable pediatric rheumatologists to diagnose juvenile SpA patients earlier
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참고문헌 (31)
참고문헌 신청
Cassidy JT / 2011 / Textbook of pediatric rheumatology / Elesevier Saunders :211
심영석 / 2012 / 소아 류마티스관절염과 Ebstein Barr Virus 감염 / 대한류마티스학회지 19(1):19~24
Nepom B / 1991 / The immunogenetics of juvenile rheumatoid arthritis / Rheum Dis Clin North Am 17:825~842
Petty RE / 1998 / Etiology and pathogenesis of rheumatic diseases of adolescence / Adolesc Med 9:11~24
Queiro R / 2003 / HLA antigens may influence the age of onset of psoriasis and psoriatic arthritis / J Rheumatol 30:505~507
심영석 / 2012 / 소아 류마티스관절염과 Ebstein Barr Virus 감염 / 대한류마티스학회지 19(1):19~24
Nepom B / 1991 / The immunogenetics of juvenile rheumatoid arthritis / Rheum Dis Clin North Am 17:825~842
Petty RE / 1998 / Etiology and pathogenesis of rheumatic diseases of adolescence / Adolesc Med 9:11~24
Queiro R / 2003 / HLA antigens may influence the age of onset of psoriasis and psoriatic arthritis / J Rheumatol 30:505~507
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