지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective. Juvenile rheumatoid arthritis (JRA) may occur in the wake of infection with several viruses including Ebstein-barr virus (EBV). EBV remains an interesting target. To determine the possible role of EBV infections in the clinical course of JRA, we attempt to demonstrate the radiologic changes and the frequency prescription of etanercept rather than classic therapy.
Methods. Total of 87 patients with JRA, who were hospitalized in Hangang Sacred Hospital and Kangnam Sacred Hospital in Seoul from 2002 to 2010, were assessed serologically for EBV infection (anti EBV VCA IgM and IgG) at admission. Patients with JRA were devided 2 groups, one is EBV VCA IgG (+) JRA patients who had been infected before and another is EBV VCA IgG (-) JRA patients who had not.
Results. EBV VCA IgG (+) were seen in 55 patients (63.2%). 31 boys (76%) and 24 girls (52%) were infected with EBV. The mean age of patients of EBV (+) JRA was 8.2±3.6 years and that of EBV (-) JRA was 5.3±3.4 years. 7 of EBV (+) JRA (13%) developed radiologic change within 2 years, compare with none of EBV (-) JRA. 22 of EBV (+) JRA (49%) with JRA did not respond to the classic therapy, compare with 7 of EBV (-) JRA (22%).
Conclusion. JRA patients with past EBV infection were older in ages, more in male, more radiologic changes, needed more biologic treatment than those without past EBV infection.
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참고문헌 (29)
참고문헌 신청
Jacobs JC / 1993 / Pediatric rheumatology for the practitioner. 2nd ed / Springer-Verlag :231~359
Brewer EJ Jr / 1977 / Current proposed revision of JRA Criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of The Arthritis Foundation / Arthritis Rheum 20(2):195~199
Cassidy JT / 2005 / Juvenile rheumatoid arthritis, In Textbook of pediatric rheumatology. 5th ed / Elsevier Saunders Co :218~321
Tosato G / 1984 / Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis / J Clin Invest 73:1789~1795
van Eden W / 1989 / A cartilage-mimicking T-cell epitope on a 65K mycobacterial heat-shock protein: adjuvant arthritis as a model for human rheumatoid arthritis / Curr Top Microbiol Immunol 145:27~43
Brewer EJ Jr / 1977 / Current proposed revision of JRA Criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of The Arthritis Foundation / Arthritis Rheum 20(2):195~199
Cassidy JT / 2005 / Juvenile rheumatoid arthritis, In Textbook of pediatric rheumatology. 5th ed / Elsevier Saunders Co :218~321
Tosato G / 1984 / Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis / J Clin Invest 73:1789~1795
van Eden W / 1989 / A cartilage-mimicking T-cell epitope on a 65K mycobacterial heat-shock protein: adjuvant arthritis as a model for human rheumatoid arthritis / Curr Top Microbiol Immunol 145:27~43
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