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자료유형
학술저널
저자정보
정성수 (서울아산병원) 서동인 (서울대학교병원) 이소연 (울산대학교) 윤지선 (서울아산병원) 조현주 (가톨릭관동대학교) 김영호 (울산대학교) 양송이 (한림대학교 성심병원) 권지원 (분당서울대학교병원) 장광천 (국민건강보험공단 일산병원) 선용한 (가천대학교 길병원) 우성일 (충북대학교) 윤유숙 (가톨릭대학교) 박강서 (예수병원) 조화진 (전남대학교) 국명희 (광주보훈병원) 이혜령 (광주보훈병원) 정혜리 (대구가톨릭대학교) 김자형 (울산병원) 김형영 (양산부산대학교병원) 정진아 (동아대학교) 우향옥 (경상대학교) 홍수종 (울산대학교)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.10 No.5
발행연도
2018.1
수록면
466 - 477 (12page)

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Background: A US Food and Drug Administration (FDA)-approved drug methacholine chloride (Provocholine®) was recently introduced to Korea where it is now widely used in clinical practice. We aimed to evaluate the prevalence, risk factors and cutoff value of bronchial hyperresponsiveness (BHR) to Provocholine in 7-year-old children. Methods: Six hundred and thirty-three children from the Panel Study on Korean Children who visited 16 regional hospitals were evaluated. Skin prick tests, spirometry and bronchial provocation tests for Provocholine as well as a detailed history and physical examinations were performed. The bronchial provocation test was reliably performed on 559 of these children. Results: The prevalence of ever-diagnosed asthma via medical records was 7.7%, and that of current asthma (wheezy episode in the last 12 months + diagnosed asthma by physicians) was 3.2%. The prevalence of BHR to Provocholine was 17.2% and 25.8%, respectively, for a PC20 < 8 and < 16 mg/mL. The risk factors for BHR (PC20 < 16 mg/mL) were atopic dermatitis diagnosis and current dog ownership, whereas those for current asthma were allergy rhinitis diagnosis, a history of bronchiolitis before the age of 3, recent use of analgesics/antipyretics and maternal history of asthma. The BHR prevalence trend showed an increase along with the increased immunoglobulin E (IgE) quartile. The cutoff value of PC20 for the diagnosis of current asthma in children at age 7 was 5.8 mg/mL (sensitivity: 47.1%, specificity: 87.4%). Conclusions: BHR to Provocholine (PC20 < 8 mg/mL) was observed in 17.2% of 7-year-olds children from the general population and the cutoff value of PC20 for the diagnosis of current asthma was 5.8 mg/mL in this age group. The risk factors for BHR and current asthma showed discrepancies suggesting different underlying mechanisms. Bronchial provocation testing with Provocholine will be a useful clinical tool in the future.

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