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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.10 No.2
- 발행연도
- 2018.1
- 수록면
- 172 - 179 (8page)
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Purpose: Bisphenol A (BPA) exposure may increase the risk of asthma. Genetic polymorphisms of oxidative stress-related genes, glutathione Stransferases (GSTM1, GSTP1), manganese superoxide dismutase, catalase, myeloperoxidase, and microsomal epoxide hydrolase may be related to BPA exposure. The aim is to evaluate whether oxidative stress genes modulates associations of BPA exposure with asthma. Methods: We conducted a case-control study comprised of 126 asthmatic children and 327 controls. Urine Bisphenol A glucuronide (BPAG) levels were measured by ultra-performance liquid chromatography/tandem mass spectrometry, and genetic variants were analyzed by a TaqMan assay. Information on asthma and environmental exposure was collected. Analyses of variance and logistic regressions were performed to determine the association of genotypes and urine BPAG levels with asthma. Results: BPAG levels were significantly associated with asthma (adjusted odds ratio [aOR], 1.29 per log unit increase in concentration; 95% confidence interval [CI], 1.081.55). Compared to the GG genotype, children with a GSTP1 AA genotype had higher urine BPAG concentrations (geometric mean [standard error], 12.72 [4.16] vs 11.42 [2.82]; P=0.036). In children with high BPAG, the GSTP1 AA genotype was related to a higher odds of asthma than the GG genotype (aOR, 4.84; 95% CI, 1.0223.06). Conclusions: GSTP1 variants are associated with urine BPA metabolite levels. Oxidative stress genes may modulate the effect of BPA exposure on asthma.
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참고문헌 (49)
참고문헌 신청
Bhan A / 2014 / Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo / J Steroid Biochem Mol Biol 141:160~170
Dodson RE / 2012 / Endocrine disruptors and asthma-associated chemicals in consumer products / Environ Health Perspect 120:935~943
Gregoraszczuk EL / 2013 / Endocrine-disrupting chemicals: some actions of pops on female reproduction / Int J Endocrinol 2013:828532
Teeguarden JG / 2013 / A systematic review of Bisphenol A "low dose" studies in the context of human exposure: a case for establishing standards for reporting "low-dose" effects of chemicals / Food Chem Toxicol 62:935~948
Rochester JR / 2013 / Bisphenol A and human health: a review of the literature / Reprod Toxicol 42:132~155
Dodson RE / 2012 / Endocrine disruptors and asthma-associated chemicals in consumer products / Environ Health Perspect 120:935~943
Gregoraszczuk EL / 2013 / Endocrine-disrupting chemicals: some actions of pops on female reproduction / Int J Endocrinol 2013:828532
Teeguarden JG / 2013 / A systematic review of Bisphenol A "low dose" studies in the context of human exposure: a case for establishing standards for reporting "low-dose" effects of chemicals / Food Chem Toxicol 62:935~948
Rochester JR / 2013 / Bisphenol A and human health: a review of the literature / Reprod Toxicol 42:132~155
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