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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.10 No.2
- 발행연도
- 2021.1
- 수록면
- 132 - 140 (9page)
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초록· 키워드
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Purpose: The objective of the present study was to evaluate the immune-enhancing potential of Salmonella Typhimurium outer membrane protein (OMP) and alum as adjuvants towards inactivated Vero cells rabies vaccine (FRV/K2). Materials and Methods: Six groups of female Sprague Dawley albino rats (10/group) were used in the evaluation of immunogenicity and safety of vaccines and adjuvants. Total immunoglobulin G secreted interferon-gamma (IFN-γ), and the percentage of proliferated CD4+ and CD8+ T cells were measured. Biochemical analysis and histopathological examination were used to test safety profiles. Results: OMP adjuvanted rabies vaccine (FRV/K2+OMP) (OMP combined locally prepared vaccine) induced significantly higher neutralizing antibodies on day 21 post-vaccination relative to free (FRV/K2) vaccine and alum adsorbed vaccine (FRV/K2+alum) (alum adsorbed locally prepared vaccine). (FRV/K2+OMP) induced a significantly higher level of IFN-γ on day 14 post-vaccination. CD8+ T cells were significantly higher post-vaccination with reference (RV), free (FRV/K2), and (FRV/K2+OMP) than (FRV/K2+alum). On the contrary, CD4+ T cells were significantly elevated post-vaccination with (FRV/K2+alum) at p<0.05. Biochemical analysis and histopathological examination revealed that OMP could be used safely as an adjuvant for the development of more effective rabies vaccines. Conclusion: Outer membrane proteins adjuvanted rabies vaccines would be beneficial to induce rapid neutralizing antibodies and essential cytokines.
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참고문헌 (36)
참고문헌 신청
Hicks DJ / 2012 / Developments in rabies vaccines / Clin Exp Immunol 169:199~204
World Health Organization / WHO expert consultation on rabies: second report
Yang Y / 2015 / The inability of wild-type rabies virus to activate dendritic cells is dependent on the glycoprotein and correlates with its low level of the de novo-synthesized leader RNA / J Virol 89:2157~2169
Jayakumar R / 1990 / Studies on cell-mediated immune response to rabies virus immunization in dogs / Vaccine 8:304~305
Thraenhart O / 1994 / Long-term humoral and cellular immunity after vaccination with cell culture rabies vaccines in man / Clin Immunol Immunopathol 71:287~292
World Health Organization / WHO expert consultation on rabies: second report
Yang Y / 2015 / The inability of wild-type rabies virus to activate dendritic cells is dependent on the glycoprotein and correlates with its low level of the de novo-synthesized leader RNA / J Virol 89:2157~2169
Jayakumar R / 1990 / Studies on cell-mediated immune response to rabies virus immunization in dogs / Vaccine 8:304~305
Thraenhart O / 1994 / Long-term humoral and cellular immunity after vaccination with cell culture rabies vaccines in man / Clin Immunol Immunopathol 71:287~292
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