Cold chain time- and temperature-controlled transport of vaccines: a simulated experimental study

Chun Zheng Ng; Yen Loong Lean; Siang Fei Yeoh; Qi Ying Lean; Kah Seng Lee; Amal Khalil Suleiman; Kai Bin Liew; Yaman Walid Kassab; Yaser Mohammed Al-Worafi; Long Chiau Ming

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저자정보: Chun Zheng Ng (Quest International University Perak) Yen Loong Lean (Quest International University Perak) Siang Fei Yeoh (National University Health System) Qi Ying Lean (Universiti Teknologi MARA) Kah Seng Lee (University of Cyberjaya) Amal Khalil Suleiman (Prince Sattam Bin Abdulaziz University) Kai Bin Liew (University of Cyberjaya) Yaman Walid Kassab (University of Cyberjaya) Yaser Mohammed Al-Worafi (University of Science and Technology of Fujairah) Long Chiau Ming (Universiti Brunei Darussalam)

저널정보: 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.9 No.1

발행연도: 2020.1

수록면: 8 - 14 (7page)

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Purpose: The objective of this research was to examine the cold chain temperature maintenance for the supply of vaccines and other biological products by pharmaceutical wholesaler. Materials and Methods: In this study, six configurations using cold vaccine boxes or bags made with different materials, with and without insulation, of different sizes, and number of coolant-packs were used to simulate the configuration used by the pharmaceutical wholesalers for transportation of vaccine. Model vaccines (vial, n=10) were packed using these six configurations which then stored in an incubator at 38ºC and monitored for 24 hours. Each configuration was tested repeatedly for 5 times. Results: In term of compliance to 2°C–8°C, four out of six tested configurations are effective in cold chain transportation. The effectiveness is highly dependent on the type of passive containers used, size of cold boxes, insulation, and number of coolant-packs. The configuration with a larger polystyrene foam box with five coolant-packs maintained the required temperature up to 23 hours. In contrast, configurations using a polystyrene foam box with four coolant-packs and a large vaccine cold box with two coolant-packs failed to reach below 8ºC throughout the 24 hours. Conclusion: Packaging method, the material and size of the container could have a direct impact on the effectiveness of cold chain temperature maintenance. Polystyrene foam box, cold box with polyethylene interior lining and polypropylene insulation, a cooler bag with proper number of ice packs could be effectively used for

#Cold chain management #Temperature #Pharmaceutical wholesaler #Transportation

참고문헌 (27)

참고문헌 신청

Department of Immunization, Vaccines and Biologicals, World Health Organization / Study protocol for temperature monitoring in the vaccine cold chain

World Health Organization / How to calculate vaccine volumes and cold chain capacity requirements (WHO/IVB/ 17.06)

Lloyd J / 2017 / The origins of the vaccine cold chain and a glimpse of the future / Vaccine 35:2115~2120

Sykes C / 2018 / Time-and temperature-controlled transport : supply chain challenges and solutions / P T 43:154~170

Hibbs BF / 2018 / Safety of vaccines that have been kept outside of recommended temperatures : reports to the Vaccine Adverse Event Reporting System(VAERS), 2008-2012 / Vaccine 36:553~558

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