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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 217 - 223 (7page)
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초록· 키워드
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Porphyromonas gingivalis, a foremost periodontal pathogen, has been known to cause periodontal diseases.
Epidemiologic evidences have indicated the involvement of P.
gingivalis in the development of cardiovascular diseases. In this study, we show that the P. gingivalis lipopolysaccharide increases the mRNA expression and protein secretion of interleukin-6 in vascular smooth muscle cells. We demonstrate that P. gingivalis LPS activates the extracellular signalregulated kinase 1/2 (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and Akt, which mediate the IL-6 expression in vascular smooth muscle cells. Also, P. gingivalis LPS stimulates the vascular smooth muscle cell migration, which is a critical step for the progression of atherosclerosis.
Moreover, neutralization of the IL-6 function inhibits the migration of vascular smooth muscle cells induced by P.
gingivalis LPS. Taken together, these results indicate that P.
gingivalis LPS promotes the expression of IL-6, which in turn increases the migration of vascular smooth muscle cells.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Sigmund S. Socransky / 1992 / The Bacterial Etiology of Destructive Periodontal Disease: Current Concepts / Journal of Periodontology 63(4s):322~331
Bainbridge BW / 2001 / Porphyromonas gingivalis lipopolysaccharide: an unusual pattern recognition receptor ligand for the innate host defense system / Acta Odontol Scand 59:131~138
Amar S / 2003 / The impact of periodontal infection on systemic diseases / Med Sci Monit 9:RA291~RA299
Koichiro Wada / 2010 / Molecular dissection of Porphyromonas gingivalis-related arteriosclerosis: a novel mechanism of vascular disease / Periodontology 2000 54(1):222~234
K. Hokamura / 2010 / Molecular analysis of aortic intimal hyperplasia caused by Porphyromonas gingivalis infection in mice with endothelial damage / Journal of Periodontal Research 45(3):337~344
Bainbridge BW / 2001 / Porphyromonas gingivalis lipopolysaccharide: an unusual pattern recognition receptor ligand for the innate host defense system / Acta Odontol Scand 59:131~138
Amar S / 2003 / The impact of periodontal infection on systemic diseases / Med Sci Monit 9:RA291~RA299
Koichiro Wada / 2010 / Molecular dissection of Porphyromonas gingivalis-related arteriosclerosis: a novel mechanism of vascular disease / Periodontology 2000 54(1):222~234
K. Hokamura / 2010 / Molecular analysis of aortic intimal hyperplasia caused by Porphyromonas gingivalis infection in mice with endothelial damage / Journal of Periodontal Research 45(3):337~344
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