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논문 기본 정보

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학술저널
저자정보
이정원 (서울대학교 의과대학 분당서울대학교병원 내과 성균관대학교 의과대학 삼성창원병원 내과) 김나영 (서울대학교 의과대학 분당서울대학교병원 내과 서울대학교 의과대학 내과학교실 간연구소) 권영재 (서울대학교 의과대학 분당서울대학교병원 내과) 이혜승 (서울대학교 의과대학 분당서울대학교병원 병리과)
저널정보
대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research Vol.19 No.2
발행연도
2019.1
수록면
120 - 126 (7page)

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Background/Aims: The incidence of gastric cancer (GC) in Korea is very high compared to that in other countries. The aim of this study was to investigate the trends of GC in patients for over 16 years. Materials and Methods: A total of 1,227 patients with GC were prospectively enrolled at Seoul National University Bundang Hospital between 2003 and 2018. Age, sex, histologic type (Lauren classification), and Helicobacter pylori (H. pylori) infection status were compared between three periods (2003~2007, 2008~2012, and 2013~2018). H. pylori infection status was evaluated based on histology, rapid urease test, culture, serology, and history of H. pylori eradication. Patients with severe atrophy or intestinal metaplasia based on histology were assumed to have previous H. pylori infection. Results: Most patients with GC underwent endoscopic mucosal resection/endoscopic submucosal dissection or another type of surgery. Early GC (EGC) and advanced GC (AGC) were detected in 769 (62.7%) and 458 (37.3%) patients, respectively, and intestinal and diffuse types were detected in 714 (58.2%) and 485 (39.5%) patients, respectively. The prevalence of EGC increased from 54.0% (252/467) to 63.5% (359/565) to 81.0% (158/195) in 2003~2007, 2008~2012, and 2013~2018, respectively. The prevalence of H. pylori-positive GC decreased from 93.4% (436/467) to 88.5% (500/565) to 82.1% (160/195) during these three periods, respectively (P<0.001). Multivariate logistic analysis showed that diffuse-type GC was continuously more prevalent in those who were younger than 50 years, who were female, and who harbored the predominant AGC type. Conclusions: Over 16 years, the prevalence of EGC increased with a decrease in H. pylori infection rate. Diffuse-type GC was continuously more common in young and female patients.

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