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논문 기본 정보

자료유형
학술저널
저자정보
Miftahussurur Muhammad (Division of Gastroentero-Hepatology Department of Internal Medicine Faculty of Medicine-Dr. Soetomo) Waskito Langgeng Agung (Institute of Tropical Disease Universitas Airlangga Surabaya Indonesia) Fauzia Kartika Afrida (Institute of Tropical Disease Universitas Airlangga Surabaya Indonesia) Mahmudah Isna (Institute of Tropical Disease Universitas Airlangga Surabaya Indonesia) Doohan Dalla (Institute of Tropical Disease Universitas Airlangga Surabaya Indonesia) Adnyana I Ketut (Department of Pharmacology and Clinical Pharmacy School of Pharmacy Institut Teknologi Bandung Band) Khomsan Ali (Department of Community Nutrition Faculty of Human Ecology IPB University Bogor Indonesia) Ratnasari Neneng (Department of Internal Medicine Faculty of Medicine Public Health and Nursing Universitas Gadjah Ma) Rezkitha Yudith Annisa Ayu (Institute of Tropical Disease Universitas Airlangga Surabaya IndonesiaFaculty of Medicine Muhammadi)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제5호
발행연도
2021.9
수록면
653 - 665 (13page)
DOI
10.5009/gnl20019

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초록· 키워드

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Helicobacter pylori infects more than half the human population. However, the prevalence in Indonesia is low, as is the prevalence of gastric cancer. Hence, it could be instructive to compare these prevalence rates and their determining factors with those of countries that have high gastric cancer incidence. Ethnicity and genetic characteristics of H. pylori are important determinants of the H. pylori infection rate in Indonesia. The infection rate is higher in Bataknese, Papuans and Buginese than in Javanese, the predominant ethnic group. Ethnicity is also an important determinant of the genetic characteristics of H. pylori. Analysis of CagA in the EPIYA segment showed that the predominant genotypes in Papuans, Bataknese and Buginese are ABB-, ABDand ABC-type CagA, respectively. Meanwhile, in the countries with high gastric cancer incidence, almost all strains had East Asian type CagA. An antibiotic susceptibility evaluation showed that the standard triple therapy can still be used with caution in several cities. There is a very high rate of resistance to second-line regimens such as levofloxacin and metronidazole. Recent studies have shown that furazolidone, rifabutin and sitafloxacin are potential alternative treatments for antibiotic-resistant H. pylori infection in Indonesia. Rather than focusing on early detection and eradication as in countries with high gastric cancer prevalence, countries with low gastric cancer prevalence should focus on screening the several groups that have a high risk of gastric cancer.

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