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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 731 - 745 (15page)
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Background: Three-dimensional (3D) cell cultures with architectural and biomechanical properties similar to those of natural tissue have been the focus for generating liver tissue. Microarchitectural organization is believed to be crucial to hepatic function, and 3D cell culture technologies have enabled the construction of tissue-like microenvironments, thereby leading to remarkable progress in vitro models of human tissue and organs. Recently, to recapitulate the 3D architecture of tissues, spheroids and organoids have become widely accepted as new practical tools for 3D organ modeling. Moreover, the combination of bioengineering approach offers the promise to more accurately model the tissue microenvironment of human organs. Indeed, the employment of sophisticated bioengineered liver models show long-term viability and functional enhancements in biochemical parameters and disease-orient outcome. Results: Various 3D in vitro liver models have been proposed as a new generation of liver medicine. Likewise, new biomedical engineering approaches and platforms are available to more accurately replicate the in vivo 3D microarchitectures and functions of living organs. This review aims to highlight the recent 3D in vitro liver model systems, including micropatterning, spheroids, and organoids that are either scaffold-based or scaffold-free systems. Finally, we discuss a number of challenges that will need to be addressed moving forward in the field of liver tissue engineering for biomedical applications. Conclusion: The ongoing development of biomedical engineering holds great promise for generating a 3D biomimetic liver model that recapitulates the physiological and pathological properties of the liver and has biomedical applications.
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참고문헌 (146)
참고문헌 신청
Duval K / 2017 / Modeling physiological events in 2D vs. 3D cell culture / Physiology (Bethesda) 32:266~277
Kapałczynska M / 2018 / 2D and 3D cell cultures—a comparison of different types of cancer cell cultures / Arch Med Sci 14:910~919
Zeigerer A / 2017 / Functional properties of hepatocytes in vitro are correlated with cell polarity maintenance / Exp Cell Res 350:242~252
Lazaro CA / 2003 / Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes / Hepatology 38:1095~1106
Bell CC / 2018 / Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications : a multicenter study / Toxicol Sci 162:655~666
Kapałczynska M / 2018 / 2D and 3D cell cultures—a comparison of different types of cancer cell cultures / Arch Med Sci 14:910~919
Zeigerer A / 2017 / Functional properties of hepatocytes in vitro are correlated with cell polarity maintenance / Exp Cell Res 350:242~252
Lazaro CA / 2003 / Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes / Hepatology 38:1095~1106
Bell CC / 2018 / Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications : a multicenter study / Toxicol Sci 162:655~666
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