지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Systemic lupus erythematosus is a typical autoimmune disease with a complex etiology, including the interaction of genetic/epigenetic factors and environmental and hormonal factors with innate immune cells or B/T lymphocytes. Studies on possible therapeutic targets have been conducted in recent decades, motivated by developments in immunology and molecular engineering. The current treatment guidelines recommend conventional immunomodulation with glucocorticoid and antimalarial agents depending on disease severity. However, targeted therapy based on the diverse disease pathophysiology is still not established and widely applied. Furthermore, although rituximab, belimumab, and other conventional immunomodulators have been approved by the Food and Drug Administration and are widely used, several clinical trials testing other biological products have failed to show satisfactory results. This review introduces novel biological agents that can potentially improve therapeutic performance in patients with systemic lupus erythematosus. These agents include humanized anti-CD20, anti-CD22, and anti-CD40L antibody; interferon α inhibitor; rigerimod; Bruton’s tyrosine kinase; and immunocomplex blockers.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Merrill JT / 2010 / Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus : the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial / Arthritis Rheum 62:222~223
Rovin BH / 2012 / Efficacy and safety of rituximab in patients with active proliferative lupus nephritis : the Lupus Nephritis Assessment with Rituximab study / Arthritis Rheum 64:1215~1226
Rios-Garces R / 2020 / Treat-to-target in systemic lupus erythematosus: where are we? / Eur J Intern Med 74:29~34
Luo S / 2020 / Recent advances in understanding pathogenesis and therapeutic strategies of Systemic Lupus Erythematosus / Int Immunopharmacol 89:107028
Iaccarino L / 2015 / Efficacy and safety of off-label use of rituximab in refractory lupus : data from the Italian Multicentre Registry / Clin Exp Rheumatol 33:449~456
Rovin BH / 2012 / Efficacy and safety of rituximab in patients with active proliferative lupus nephritis : the Lupus Nephritis Assessment with Rituximab study / Arthritis Rheum 64:1215~1226
Rios-Garces R / 2020 / Treat-to-target in systemic lupus erythematosus: where are we? / Eur J Intern Med 74:29~34
Luo S / 2020 / Recent advances in understanding pathogenesis and therapeutic strategies of Systemic Lupus Erythematosus / Int Immunopharmacol 89:107028
Iaccarino L / 2015 / Efficacy and safety of off-label use of rituximab in refractory lupus : data from the Italian Multicentre Registry / Clin Exp Rheumatol 33:449~456
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
전신홍반루푸스의 새로운 분류 기준
대한내과학회지
2020 .06
-
전신홍반루푸스의 치료
대한내과학회지
2020 .06
-
Mouse models of systemic lupus erythematosus
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Relapsing lupus enteritis in systemic lupus erythematosus
Kidney Research and Clinical Practice
2016 .01
-
A Case of Psoriasis Accompanied by Systemic Lupus Erythematosus
Annals of Dermatology
2015 .01
-
자가면역용혈빈혈로 발현되어 루푸스로 오인된 T세포 림프종 1예
대한내과학회지
2017 .06
-
Calcifications on the Entire Legs of a Systemic Lupus Erythematosus Patient
Archives of plastic surgery : APS
2016 .01
-
루푸스 환자의 스트레스와 치료지시이행의 관계에 미치는 극복력의 매개효과
근관절건강학회지
2017 .12
-
Combination therapy of cyclosporine and prednisolone in a dog with systemic lupus erythematosus
Korean Journal of Veterinary Research(대한수의학회지)
2016 .05
-
Anti-N-Methyl-D-Aspartate Receptor Encephalitis in a Patient with Systemic Lupus Erythematosus
Journal of Clinical Neurology
2016 .01
-
Brain meningioma in a patient with systemic lupus erythematosus
영남의대학술지
2016 .01
-
Targeted Immunotherapy for Autoimmune Disease
Immune Network
2022 .02
-
전신홍반루푸스로 오인된 혈관내B대세포림프종 1예
대한내과학회지
2015 .01
-
Analysis of the Prevalence of Deep Vein Thrombosis in Systemic Lupus Erythematosus in Korea: A Nation-wide Cohort Study
대한외과학회 학술대회 초록집
2021 .11
-
급성 타액선염으로 발현되어 중추신경계를 침범한 전신홍반루푸스 1예
대한이비인후-두경부외과학회지
2015 .01
-
전신홍반루푸스와 동반된 고칼슘혈증 증례
대한내과학회지
2017 .06
-
전신홍반루푸스에 동반된 불응성 혈구포식 림프조직구증식증에서Tocilizumab 치료 1예
대한내과학회지
2015 .01
-
A Comprehensive Rehabilitation Approach in a Patient With Serious Neuropsychiatric Systemic Lupus Erythematosus
Annals of Rehabilitation Medicine
2016 .01
-
루푸스 환자에서 예방접종
대한내과학회지
2020 .06
-
Psychiatric Symptoms in Systemic Lupus Erythematosus: Diagnosis and Treatment
대한류마티스학회지
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0