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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 12 - 20 (9page)
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Sporadic conventional colon adenomas are microscopically built of 2 intertwined compartments: one on top, harboring the dysplastic tissue that defines their histo-biomolecular attributes, and the other below, composed of non-dysplastic crypts with corrupted shapes (CCS). The CCS of 306 colon adenomas revealed asymmetric, haphazardly-distributed proliferating cell-domains (PC). In contrast, the PC-domains in normal controls were symmetric, being limited to the lower thirds of the crypts. In 28% out of 501 sporadic conventional adenomas, foci of p53-upregulated dysplastic tissue were found. The CCS in 30% of 108 sporadic adenomas showed p53-upregulated single cells, suggesting mounting somatic mutations. No p53-upregulated cells were found in the crypts of controls. In polypoid adenomas, the mucosa of the stalk without dysplastic tissue on top disclosed CCS with asymmetrical PC-domains and single p53-upregulated cells. The latter observations suggested that CCS had developed prior to and not after the growth of the dysplastic tissue on top. CCS were also found below colon adenomas in carcinogen-treated rats. It is concluded that the 2 intertwined histo-biological compartments of sporadic conventional colon adenomas are probably interdependent components. These findings may open new directions aimed to uncover the link between the normal colonic mucosa and the histogenesis of, conventional adenomas.
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참고문헌 (60)
참고문헌 신청
Dahl J / 2007 / Histology for pathologists / Lippincott Williams & Wilkins :627~648
Baker AM / 2019 / Crypt fusion as a homeostatic mechanism in the human colon / Gut 68:1986~1993
Boman BM / 2013 / An APC : WNT counter-current-like mechanism regulates cell division along the human colonic crypt axis : a mechanism that explains how APC mutations induce proliferative abnormalities that drive colon cancer development / Front Oncol 3:244
Rubio CA / 2018 / The histologic structure of the large bowel mucosa and the evolution of the three pathways of colonic carcinogenesis in humans and in experimental animals / Recent Stud Dig Syst Anat 3:1~12
Levine DS / 1989 / Normal histology of the colon / Am J Surg Pathol 13:966~984
Baker AM / 2019 / Crypt fusion as a homeostatic mechanism in the human colon / Gut 68:1986~1993
Boman BM / 2013 / An APC : WNT counter-current-like mechanism regulates cell division along the human colonic crypt axis : a mechanism that explains how APC mutations induce proliferative abnormalities that drive colon cancer development / Front Oncol 3:244
Rubio CA / 2018 / The histologic structure of the large bowel mucosa and the evolution of the three pathways of colonic carcinogenesis in humans and in experimental animals / Recent Stud Dig Syst Anat 3:1~12
Levine DS / 1989 / Normal histology of the colon / Am J Surg Pathol 13:966~984
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