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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 78 - 86 (9page)
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초록· 키워드
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Background/Aims: Four high-quality randomized controlled trials have proven the efficacy of fecal microbiota transplantation(FMT) in active ulcerative colitis (UC). We assessed the efficacy of FMT in a real-world setting involving steroid-dependentpatients with UC. Methods: This was a single-center prospective analysis of data from steroid-dependent patients with UCtreated with FMT from September 2015 to September 2017 at the Dayanand Medical College, a tertiary care center in India. Fecal samples from random unrelated donors were administered through colonoscopy at weeks 0, 2, 6, 10, 14, 18, and 22. Theprimary outcome was achievement of steroid-free clinical remission, and the secondary outcomes were clinical response andendoscopic remission at 24 weeks. Modified intention-to-treat analysis was performed, which included subjects who underwentat least 1 FMT. Results: Of 345 patients with UC treated during the study period, 49 (14.2%) had steroid-dependent UC. Of these 49 patients, 41 underwent FMT: 33 completed 7 sessions over 22 weeks according to the protocol, and 8 discontinuedtreatment (non-response, 5; lost to follow-up, 2; and fear of adverse effects, 1). At week 24, steroid-free clinical remission wasachieved in 19 out of 41 (46.3%) patients, whereas clinical response and endoscopic remission were achieved in 31 out of 41(75.6%) and 26 out of 41 (63.4%) patients, respectively. All patients with clinical response were able to withdraw steroids. Therewere no serious adverse events necessitating discontinuation. Conclusions: A multisession FMT via the colonoscopic routeis a promising therapeutic option for patients with steroid-dependent UC, as it can induce clinical remission and aid in steroidwithdrawal. (Intest Res 2019;17:78-86)
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참고문헌 (34)
참고문헌 신청
Ekbom A / 1992 / Survival and causes of death in patients with inflammatory bowel disease : a population-based study / Gastroenterology 103:954~960
Fraser AG / 2002 / The efficacy of azathioprine for the treatment of inflammatory bowel disease : a 30 year review / Gut 50:485~489
Ardizzone S / 2006 / Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis / Gut 55:47~53
Adler DJ / 1990 / The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis / Am J Gastroenterol 85:717~722
Rutgeerts P / 2005 / Infliximab for induction and maintenance therapy for ulcerative colitis / N Engl J Med 353:2462~2476
Fraser AG / 2002 / The efficacy of azathioprine for the treatment of inflammatory bowel disease : a 30 year review / Gut 50:485~489
Ardizzone S / 2006 / Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis / Gut 55:47~53
Adler DJ / 1990 / The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis / Am J Gastroenterol 85:717~722
Rutgeerts P / 2005 / Infliximab for induction and maintenance therapy for ulcerative colitis / N Engl J Med 353:2462~2476
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