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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Chronic pancreatitis (CP) is an irreversible progressive disease that destroys exocrine parenchyma, which are replaced by fibrous tissue. As pancreatic fibrosis is a key feature of CP, reducing fibrotic protein content in the pancreas is crucial for preventing CP. Studies suggest that NF-B facilitates the expression of fibrotic mediators in pancreas and protein kinase C- (PKC-) regulates NF-B activation in stimulated pancreatic acinar cells. Docosahexaenoic acid (DHA) is an omega-3 fatty acid having anti-inflammatory and anti-fibrotic effects. It has been shown to inhibit NF-B activity in cerulein-stimulated pancreatic acinar cells which is a cellular model of CP. In the present study, we investigated if DHA inhibits expression of fibrotic mediators by reducing PKC- and NF-B expression in mouse pancreatic tissues with CP. Methods: For six weeks, mice were weekly induced for acute pancreatitis to develop CP. Furthermore, acute pancreatitis was induced by hourly intraperitoneal injections of cerulein (50 g/kg × 7). Mice were administered DHA (10 M) via drinking water before and after CP induction. Results: Cerulein-induced pancreatic damages like decreased pancreatic weight/total body weight, leukocyte infiltration, necrosis of acinar cells, and vacuolization were found to be inhibited by DHA. Additionally, DHA inhibited cerulein-induced fibrotic mediators like alpha-smooth muscle actin and fibronectin in pancreas. DHA reduced expression of PKC- and NF-B p65 in pancreatic tissues of cerulein-treated mice. Conclusions: DHA may be beneficial in preventing CP by suppressing pancreatic expression of fibrotic mediators. (J Cancer Prev 2019;24:233-239)
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참고문헌 (20)
참고문헌 신청
Ciappolino V / 2019 / The role of docosahexaenoic acid (DHA) on cognitive functions in psychiatric disorders / Nutrients 11:E769
Clementi ME / 2019 / DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2/HO-1 axis / Int J Mol Med 43:2523~2531
Yum HW / 2016 / Anti-inflammatory effects of docosahexaenoic acid: implications for its cancer chemopreventive potential / Semin Cancer Biol 40-41:141~159
Lytle KA / 2015 / Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFβ-Smad3 pathway / J Lipid Res 56:1936~1946
Holub BJ / 2009 / Docosahexaenoic acid (DHA) and cardiovascular disease risk factors / Prostaglandins Leukot Essent Fatty Acids 81:199~204
Clementi ME / 2019 / DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2/HO-1 axis / Int J Mol Med 43:2523~2531
Yum HW / 2016 / Anti-inflammatory effects of docosahexaenoic acid: implications for its cancer chemopreventive potential / Semin Cancer Biol 40-41:141~159
Lytle KA / 2015 / Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr-/- mice by targeting the TGFβ-Smad3 pathway / J Lipid Res 56:1936~1946
Holub BJ / 2009 / Docosahexaenoic acid (DHA) and cardiovascular disease risk factors / Prostaglandins Leukot Essent Fatty Acids 81:199~204
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