지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Pancreatic cancer is a highly aggressive malignant tumor of the digestive system and radical resection, which is available to very few patients, might be the only possibility for cure. Since therapeutic choices are limited at the advanced stage, prevention is more important for reducing incidence in high-risk individuals with family history of pancreatic cancer. Epidemiological studies have shown that a high consumption of fish oil or ω3-polyunsaturated fatty acids reduces the risk of pancreatic cancers. Dietary fish oil supplementation has shown to suppress pancreatic cancer development in animal models. Previous experimental studies revealed that several hallmarks of cancer involved in the pathogenesis of pancreatic cancer, such as the resistance to apoptosis, hyper-proliferation with abnormal Wnt/β-catenin signaling, expression of pro-angiogenic growth factors, and invasion. Docosahexaenoic acid (DHA) is a ω3-polyunsaturated fatty acid and rich in cold oceanic fish oil. DHA shows anti-cancer activity by inducing oxidative stress and apoptosis, inhibiting Wnt/β-catenin signaling, and decreasing extracellular matrix degradation and expression of pro-angiogenic factors in pancreatic cancer cells. This review will summarize anti-cancer mechanism of DHA in pancreatic carcinogenesis based on the recent studies.
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등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Zhang Q / 2017 / New developments in the early diagnosis of pancreatic cancer / Expert Rev Gastroenterol Hepatol 11:149~156
Hidaka A / 2015 / Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study / Am J Clin Nutr 102:1490~1497
Macášek J / 2012 / Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters / Nutr Cancer 64:946~955
He K / 2013 / Types of fish consumed and fish preparation methods in relation to pancreatic cancer incidence: the VITAL Cohort Study / Am J Epidemiol 177:152~160
Mohammed A / 2012 / Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice / Neoplasia 14:1249~1259
Hidaka A / 2015 / Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study / Am J Clin Nutr 102:1490~1497
Macášek J / 2012 / Plasma fatty acid composition in patients with pancreatic cancer: correlations to clinical parameters / Nutr Cancer 64:946~955
He K / 2013 / Types of fish consumed and fish preparation methods in relation to pancreatic cancer incidence: the VITAL Cohort Study / Am J Epidemiol 177:152~160
Mohammed A / 2012 / Endogenous n-3 polyunsaturated fatty acids delay progression of pancreatic ductal adenocarcinoma in Fat-1-p48(Cre/+)-LSL-Kras(G12D/+) mice / Neoplasia 14:1249~1259
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