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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Baicalein is a bioactive flavone that is originally extracted from the root of Scutellaria baicalensis Georgi. This plant has long served as Chinese herbal medicine in the management of multiple diseases including inflammatory bowel diseases. Although it has been revealed that baicalein inhibits experimental colitis in mice, the molecular mechanisms still remain largely unrecognized. Methods: The experimental colitis was induced in mice by 3% dextran sulfate sodium (DSS) in drinking water. The mice were given baicalein (10 or 25 mg/kg) by gavage for 7 days before and after DSS administration. Expression of COX-2 and inducible nitric oxide synthase (iNOS) and molecules involved in NF-B signaling, such as inhibitor of (IB), pIB, p65, and phospho-p65 was examined by Western blot analysis in the tissue of the mouse colon. Activity of IB kinase (IKK) was assessed by measuring the relative amount of radioactive -phosphate of ATP transferred to the IB substrate protein. The expression and phosphorylation of STAT3 and its target gene cyclin D1 were also measured. Results: Baicalein prominently mitigated the severity of DSS-induced colitis in mice. It inhibited the expression of COX-2 and iNOS. Moreover, baicalein attenuated activity and phosphorylation of IKK and subsequent degradation of IB. Baicalein suppressed the phosphorylation and nuclear translocation of p65, resulting in a reduced DNA binding activity of NF-B. Baicalein also suppressed the phosphorylation of STAT3 and expression of cyclin D1. Baicalein exhibited the synergistic effect on inhibition of COX-2 induced by DSS with curcumin, an ingredient of turmeric. Conclusions: Protective effects of baicalein on DSS-induced colitis are associated with suppression of NF-B and STAT3 signaling pathways, which may contribute to its cancer preventive effects on colon carcinogenesis. (J Cancer Prev 2019;24:129-138)
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참고문헌 (54)
참고문헌 신청
Tomasello G / 2014 / Dismicrobism in inflammatory bowel disease and colorectal cancer: changes in response of colocytes / World J Gastroenterol 20:18121~18130
Wang D / 2010 / The role of COX-2 in intestinal inflammation and colorectal cancer / Oncogene 29:781~788
Menter DG / 2010 / Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward / Clin Cancer Res 16:1384~1390
Aktan F / 2004 / iNOS-mediated nitric oxide production and its regulation / Life Sci 75:639~653
Keklikoglu N / 2008 / iNOS expression in oral and gastrointestinal tract mucosa / Dig Dis Sci 53:1437~1442
Wang D / 2010 / The role of COX-2 in intestinal inflammation and colorectal cancer / Oncogene 29:781~788
Menter DG / 2010 / Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward / Clin Cancer Res 16:1384~1390
Aktan F / 2004 / iNOS-mediated nitric oxide production and its regulation / Life Sci 75:639~653
Keklikoglu N / 2008 / iNOS expression in oral and gastrointestinal tract mucosa / Dig Dis Sci 53:1437~1442
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