Prognostic significance of lymphovascular space invasion in patients with endometrioid endometrial cancer: a retrospective study from a single center

Yibo Dai; Yangyang Dong; Yuan Cheng; Hongyi Hou; Jingyuan Wang; Zhiqi Wang; Jianliu Wang

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자료유형: 학술저널

저자정보: Yibo Dai (Peking University People's Hospital) Yangyang Dong (Peking University People's Hospital) Yuan Cheng (Peking University People's Hospital) Hongyi Hou (Peking University People's Hospital) Jingyuan Wang (Peking University People's Hospital) Zhiqi Wang (Peking University People's Hospital) Jianliu Wang (Peking University People's Hospital)

저널정보: 대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.31 No.3

발행연도: 2020.1

수록면: 1 - 12 (12page)

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Objective: This study aims to analyze factors associated with lymphovascular space invasion (LVSI) and evaluate the prognostic significance of LVSI in Chinese endometrioid endometrial cancer (EEC) patients. Methods: Five-hundred eighty-four EEC patients undergoing surgery in our center from 2006 to 2016 were selected for analysis. Univariate analysis and multivariate logistic regression were used to examine relevant factors of LVSI. To evaluate the prognostic role of LVSI, survival analyses were conducted. In survival analyses, both multivariate Cox regression and propensity score matching were used to control the confounders. Results: The incidence of LVSI was 12.16% (71/584). Diabetes history (p=0.021), lymph node metastasis (p=0.005), deep myometrial invasion (p<0.001) and negative PR expression (p=0.007) were independently associated with LVSI. Both Kaplan-Meier method and univariate Cox regressions showed LVSI negative and positive cases had similar tumor-specific survival (TSS) and disease-free survival (DFS). After adjusting for the influence of adjuvant therapy and other clinicopathological factors with multivariate Cox regressions, LVSI still could not bring additional survival risk to the patients (p=0.280 and p=0.650 for TSS and DFS, respectively). This result was verified by Kaplan-Meier survival analyses after propensity score matching (p=0.234 and p=0.765 for TSS and DFS, respectively). Conclusion: LVSI does not significantly compromise the survival outcome of Chinese EEC patients.

#Endometrial Neoplasms #Lymphovascular Space Invasion #Recurrence #Survival

참고문헌 (28)

참고문헌 신청

Siegel RL / 2018 / Cancer statistics, 2018 / CA Cancer J Clin 68:7~30

Chen W / 2018 / Cancer incidence and mortality in China, 2014 / Chin J Cancer Res 30:1~12

Brooks RA / 2019 / Current recommendations and recent progress in endometrial cancer / CA Cancer J Clin 69:258~279

Sadozye AH / 2016 / Lymphovascular space invasion as a risk factor in early endometrial cancer / Curr Oncol Rep 18:24

Cohn DE / 2002 / Should the presence of lymphvascular space involvement be used to assign patients to adjuvant therapy following hysterectomy for unstaged endometrial cancer? / Gynecol Oncol 87:243~246

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