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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

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학술저널
저자정보
Casper Reijnen (Radboud University Medical Center Nijmegen) Nicole CM Visser (Department of Pathology Radboud University Medical Center) Jenneke C Kasius (Centre of Gynaecologic Oncology Amsterdam Academic Medical Center) Dorry Boll (Catharina Hospital Eindhoven) Peggy M Geomini (Màxima Medical Centre Veldhoven) Huy Ngo (Elkerliek Hospital Helmond) Dennis van Hamont (Amphia Hospital Breda) Brenda M Pijlman (Jeroen Bosch Hospital 's-Hertogenbosch) Maria Caroline Vos (Elisabeth-Tweesteden Hospital Tilburg) Johan Bulten (Department of Pathology Radboud University Medical Center) Marc PLM Snijders (Canisius-Wilhelmina Hospital Nijmegen) Leon FAG Massuger (Radboud University Medical Centre) Johanna MA Pijnenborg (Radboud University Medical Center)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.30 No.5
발행연도
2019.1
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1 - 11 (11page)

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Objectives The global obesity epidemic has great impact on the prevalence of low-grade endometrial carcinoma. The preoperative tumor serum marker cancer antigen 125 (CA-125) might contribute to improved identification of high-risk patients within this group. The study aimed to investigate the prognostic value of CA-125 in relation to established preoperative prognosticators, with a focus on identifying patients with poor outcome in low-grade endometrial carcinoma (EC) patients. Methods Prospective multicenter cohort study including all consecutive patients surgically treated for endometrial carcinoma in nine collaborating hospitals from September 2011 until December 2013. All preoperative histopathological diagnoses were reviewed in a blinded manner. Associations between CA-125 and clinicopathological features were determined. Univariable and multivariable analysis by Cox regression were used. Separate analyses were performed for preoperatively designated low-grade and high-grade endometrial carcinoma patients. Results A total of 333 patients were analyzed. CA-125 was associated with poor prognostic features including advanced International Federation of Gynecology and Obstetrics (FIGO) stage. In multivariable analysis, age, preoperative tumor and CA-125 were significantly associated with disease-free survival (DFS); preoperative grade, tumor type, FIGO and CA-125 were significantly associated with disease-specific survival (DSS). Low-grade EC patients with elevated CA-125 revealed a DFS of 80.6% and DSS of 87.1%, compared to 92.1% and 97.2% in low-grade EC patients with normal CA-125. Conclusion Preoperative elevated CA-125 was associated with poor prognostic features and independently associated with DFS and DSS. Particularly patients with low-grade EC and elevated CA-125 represent a group with poor outcome and should be considered as high-risk endometrial carcinoma.
#CA-125 Antigen #Endometrial Neoplasms #Low-grade Carcinoma #Biomarkers #Risk Stratification

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참고문헌 (34)

참고문헌 신청
Jemal A / 2011 / Global cancer statistics / CA Cancer J Clin 61:69~90 google schola Pearson-Stuttard J / 2018 / Worldwide burden of cancer attributable to diabetes and high body-mass index : a comparative risk assessment / Lancet Diabetes Endocrinol 6:e6~e15 google schola Boll D / 2013 / Increased incidence and improved survival in endometrioid endometrial cancer diagnosed since 1989 in The Netherlands : a population based study / Eur J Obstet Gynecol Reprod Biol 166:209~214 google schola Wang YC / 2011 / Health and economic burden of the projected obesity trends in the USA and the UK / Lancet 378:815~825 google schola Arnold M / 2015 / Global burden of cancer attributable to high body-mass index in 2012 : a population-based study / Lancet Oncol 16:36~46 google schola

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