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Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity
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Type
Academic journal
Author
Sun Ok Song (국민건강보험공단 일산병원) Ken He (Veterans Affairs Pittsburgh Healthcare System) Radhika R. Narla (University of Washington School of Medicine) Kang Hyun Goo (전북대학교) Han Uk Ryu (전북대학교 의학전문대학원 전북대학교병원 신경과) Edward J. Boyko (VA Puget Sound Health Care System)
Journal
대한당뇨병학회 Diabetes and Metabolism Journal Diabetes and Metabolism Journal Vol.43 No.2 KCI Accredited Journals
Published
2019.1
Pages
144 - 155 (12page)

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Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity
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Abstract· Keywords

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Obstructive sleep apnea (OSA) and diabetes has been known to be closely related to each other and both diseases impact highly on the public health. There are many evidence of reports that OSA is associated with diabetes with a bidirectional correlation. A possible causal mechanism of OSA to diabetes is intermittent hypoxemia and diabetes to OSA is microvascular complication. However, OSA and diabetes have a high prevalence rate in public and shares the common overlap characteristic and risk factors such as age, obesity, and metabolic syndrome that make it difficult to establish the exact pathophysiologic mechanism between them. In addition, studies demonstrating that treatment of OSA may help prevent diabetes or improve glycemic control have not shown convincing result but have become a great field of interest research. This review outlines the bidirectional correlation between OSA and diabetes and explore the pathophysiologic mechanisms by approaching their basic etiologies.
#Diabetes mellitus #Insulin resistance #Obesity #Sleep apnea syndromes

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References (107)

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Burwell CS / 1994 / Extreme obesity associated with alveolar hypoventilation : a Pickwickian syndrome 1956 / Obes Res 2:390~397 google schola American Academy of Sleep Medicine / 2014 / International classification of sleep disorders / American Academy of Sleep Medicine google schola Eckert DJ / 2013 / Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets / Am J Respir Crit Care Med 188:996~1004 google schola Young T / 1993 / The occurrence of sleep-disordered breathing among middle-aged adults / N Engl J Med 328:1230~1235 google schola Narkiewicz K / 2003 / Sympathetic nerve activity in obstructive sleep apnoea / Acta Physiol Scand 177:385~390 google schola

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