지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.25 No.3
- 발행연도
- 2019.1
- 수록면
- 442 - 460 (19page)
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Background/AimsAbdominal pain can be evoked or exacerbated after gastrointestinal cold stimulation in some patients with diarrhea-predominantirritable bowel syndrome (IBS-D), indicating a low temperature-induced sensitization of visceral perception. We investigated the roleof vagal transient receptor potential ankyrin 1 (TRPA1, a cold-sensing ion channel) in cold-aggravated visceral mechanonociception ina stress-induced IBS animal model. MethodsTRPA1 expression was examined in antral biopsies of healthy controls and IBS-D patients. Abdominal symptoms were assessed beforeand after warm or cold water intake. The visceromotor response (VMR) to colorectal distention (CRD) following intra-antral infusionof cold saline was measured in animals undergoing sham or chronic water avoidance stress. TRPA1 expression, extracellular signalregulatedprotein kinase 1/2 (ERK1/2) phosphorylation, and neuronal calcium influx in vagal afferents were assessed. ResultsCompared to healthy controls, IBS-D patients displayed elevated antral TRPA1 expression, which was associated with symptom scoresafter cold (4°C) water intake. Intra-antral infusion of cold saline increased VMR to CRD in naive rats, an effect dependent on vagalafferents. In stressed rats, this effect was greatly enhanced. Functional blockade and gene deletion of TRPA1 abolished the cold effecton visceral nociception. TRPA1 expression in vagal (but not spinal) afferents increased after stress. Moreover, the cold-induced, TRPA1-dependent ERK1/2 activation and calcium influx in nodose neurons were more robust in stressed rats. ConclusionsStress-exaggerated visceral mechanonociception after antral cold exposure may involve up-regulation of TRPA1 expression andfunction on vagal afferents. Our findings reveal a novel mechanism for abnormal gastrointestinal cold sensing in IBS.
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참고문헌 (36)
참고문헌 신청
Mohammad H Farzaei / 2016 / The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments / Journal of Neurogastroenterology and Motility (JNM) 22(4):558~574
Drossman DA / 2016 / Functional gastrointestinal disorders : history, pathophysiology, clinical features and Rome IV / Gastroenterology 150:1262~1279
Zuo XL / 2006 / Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome / J Gastroenterol 41:311~317
Wang RF / 2013 / Temperature can influence gastric accommodation and sensitivity in functional dyspepsia with epigastric pain syndrome / Dig Dis Sci 58:2550~2555
Vriens J / 2014 / Peripheral thermosensation in mammals / Nat Rev Neurosci 15:573~589
Drossman DA / 2016 / Functional gastrointestinal disorders : history, pathophysiology, clinical features and Rome IV / Gastroenterology 150:1262~1279
Zuo XL / 2006 / Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome / J Gastroenterol 41:311~317
Wang RF / 2013 / Temperature can influence gastric accommodation and sensitivity in functional dyspepsia with epigastric pain syndrome / Dig Dis Sci 58:2550~2555
Vriens J / 2014 / Peripheral thermosensation in mammals / Nat Rev Neurosci 15:573~589
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