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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 202 - 209 (8page)
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초록· 키워드
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Objectives The purpose of this study was to investigate the involvement of TRPA1 in the cinnamaldehyde-induced pulpal blood flow (PBF) change in the feline dental pulp.
Materials and Methods Mandibles of eight cats were immobilized and PBF was monitored with a laser Doppler flowmetry at the mandibular canine tooth. To evaluate the effect of cinnamaldehyde on PBF, cinnamaldehyde was injected into the pulp through the lingual artery at a constant rate for 60 seconds. As a control, a mixture of 70% ethanol and 30% dimethyl sulfoxide (DMSO, vehicle) was used. To evaluate the involvement of transient receptor potential ankyrin 1 (TRPA1) in PBF change, AP18, a specific TRPA1 antagonist, was applied into the pulp through the Class V dentinal cavity followed by cinnamaldehyde-administration 3 minutes later. The paired variables of experimental data were statistically analyzed using paired t-test. A p value of less than 0.05 was considered as statistically significant.
Results Administration of cinnamaldehyde (0.5 mg/kg, intra-arterial [i.a.]) induced significant increases in PBF (p < 0.05). While administration of a TRPA1 antagonist, AP18 (2.5 - 3.0 mM, into the dentinal cavity [i.c.]) caused insignificant change of PBF (p > 0.05), administration of cinnamaldehyde (0.5 mg/kg, i.a.) following the application of AP18 (2.5 - 3.0 mM, i.c.) resulted in an attenuation of PBF increase from the control level (p < 0.05). As a result, a TRPA1 antagonist, AP18 effectively inhibited the vasodilative effect of cinnamaldehyde (p < 0.05).
Conclusions The result of the present study provided a functional evidence that TRPA1 is involved in the mechanism of cinnamaldehyde-induced vasodilation in the feline dental pulp.
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참고문헌 (42)
참고문헌 신청
Hargreaves KM / 2011 / Cohen’s pathways of pulp / Mosby Elsevier :571
Heyeraas KJ / 1994 / Effect of electrical tooth stimulation on blood flow, interstitial fluid pressure and substance P and CGRPimmunoreactive nerve fibers in the low compliant cat dental pulp / Microvasc Res 47:329~343
Nyman E / 2013 / In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model / J Pain Res 6:59~70
Kobayashi K / 2005 / Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with delta/c-fibers and colocalization with trk receptors / J Comp Neurol 493:596~606
Salas MM / 2009 / TRPA1-mediated responses in trigeminal sensory neurons:interaction between TRPA1 and TRPV1 / Eur J Neurosci 29:1568~1578
Heyeraas KJ / 1994 / Effect of electrical tooth stimulation on blood flow, interstitial fluid pressure and substance P and CGRPimmunoreactive nerve fibers in the low compliant cat dental pulp / Microvasc Res 47:329~343
Nyman E / 2013 / In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model / J Pain Res 6:59~70
Kobayashi K / 2005 / Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with delta/c-fibers and colocalization with trk receptors / J Comp Neurol 493:596~606
Salas MM / 2009 / TRPA1-mediated responses in trigeminal sensory neurons:interaction between TRPA1 and TRPV1 / Eur J Neurosci 29:1568~1578
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