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논문 기본 정보

자료유형
학술저널
저자정보
Jason R Baker (Division of Gastroenterology University of Michigan Health System Ann Arbor MI USA) Joseph R Dickens (School of Pharmacy University of Michigan Ann Arbor MI USA) Mark Koenigsknecht (School of Pharmacy University of Michigan Ann Arbor MI USA) Ann Frances (School of Pharmacy University of Michigan Ann Arbor MI USA) Allen A Lee (Division of Gastroenterology University of Michigan Health System Ann Arbor MI USA) Kerby A Shedden (School of Pharmacy University of Michigan Ann Arbor MI USA) James G Brasseur (Department of Aerospace Engineering Sciences University of Colorado Boulder Boulder CO USA) Gordon L Amidon (School of Pharmacy University of Michigan Ann Arbor MI USA) Duxin Sun (School of Pharmacy University of Michigan Ann Arbor MI USA) William L Hasler (Division of Gastroenterology University of Michigan Health System Ann Arbor MI USA)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.25 No.1
발행연도
2019.1
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100 - 112 (13page)

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Background/Aims High-resolution methods have advanced esophageal and anorectal manometry interpretation but are incompletely established for intestinal manometry. We characterized normal fasting duodeno-jejunal manometry parameters not measurable by standard techniques using clustered closely-spaced recordings. Methods Ten fasting recordings were performed in 8 healthy controls using catheters with 3–4 gastrointestinal manometry clusters with 1–2 cm channel spacing. Migrating motor complex phase III characteristics were quantified. Spatial-temporal contour plots measured propagation direction and velocity of individual contractions. Coupling was defined by pressure peak continuity within clusters. Results Twenty-three phase III complexes (11 antral, 12 intestinal origin) with 157 (95% CI, 104–211) minute periodicities, 6.99 (6.25–7.74) minute durations, 10.92 (10.68–11.16) cycle/minute frequencies, 73.6 (67.7–79.5) mmHg maximal amplitudes, and 4.20 (3.18–5.22) cm/minute propagation velocities were recorded. Coupling of individual contractions was 39.1% (32.1–46.1); 63.0% (54.4–71.6) of contractions were antegrade and 32.8% (24.1–41.5) were retrograde. Individual phase III contractions propagated > 35 fold faster (2.48 cm/sec; 95% CI, 2.25–2.71) than complexes themselves. Phase III complexes beyond the proximal jejunum were longer in duration (P = 0.025) and had poorer contractile coupling (P = 0.025) than proximal complexes. Coupling was greater with 1 cm channel spacing vs 2 cm (P < 0.001). Conclusions Intestinal manometry using clustered closely-spaced pressure ports characterizes novel antegrade and retrograde propagation and coupling properties which degrade in more distal jejunal segments. Coupling is greater with more closely-spaced recordings. Applying similar methods to dysmotility syndromes will define the relevance of these methods.

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